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Temporal variations in ice sheet flow directly impact the internal structure within ice sheets through englacial deformation. Large-scale changes in the vertical stratigraphy within ice sheets have been previously conducted on centennial to millennial timescales; however, intra-annual changes in the morphology of internal layers have yet to be explored. Over a period of 2 years, we use autonomous phase-sensitive radio-echo sounding to track the daily displacement of internal layers on Store Glacier, West Greenland, to millimeter accuracy. At a site located ∼30 km from the calving terminus, where the ice is ∼600 m thick and flows at ∼700 m/a, we measure distinct seasonal variations in vertical velocities and vertical strain rates over a 2-year period. Prior to the melt season (March-June), we observe increasingly nonlinear englacial deformation with negative vertical strain rates (i.e., strain thinning) in the upper half of the ice column of approximately -0.03 a-1, whereas the ice below thickens under vertical strain reaching up to +0.16 a-1. Early in the melt season (June-July), vertical thinning gradually ceases as the glacier increasingly thickens. During late summer to midwinter (August-February), vertical thickening occurs linearly throughout the entire ice column, with strain rates averaging 0.016 a-1. We show that these complex variations are unrelated to topographic setting and localized basal slip and hypothesize that this seasonality is driven by far-field perturbations in the glacier's force balance, in this case generated by variations in basal hydrology near the glacier's terminus and propagated tens of kilometers upstream through transient basal lubrication longitudinal coupling.

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Stable suspensions of submicron particles of cyclosporine, a water-insoluble drug, have been produced by rapid expansion from supercritical to aqueous solution (RESAS). To minimize growth of the cyclosporine particles, which would otherwise occur in the free jet expansion, the solution was sprayed into an aqueous Tween-80 (Polysorbate-80) solution. Steric stabilization by the surfactant impedes particle growth and agglomeration. The particles were an order of magnitude smaller than those produced by RESS into air without the surfactant solution. Concentrations as high as 38 mg/mL for 400-700 nm particles were achieved in a 5.0% (w/w) Tween-80 solution.

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Lysozyme was encapsulated in biodegradable polymer microspheres which were precipitated from an organic solution by spraying the solution into carbon dioxide. The polymer, either poly(l-lactide) (l-PLA) or poly(DL-lactide-co-glycolide) (PGLA), in dichloromethane solution with suspended lysozyme was sprayed into a CO2 vapor phase through a capillary nozzle to form droplets which solidified after falling into a CO2 liquid phase. By delaying precipitation in the vapor phase, the primary particles became sufficiently large, from 5 to 70 microm, such that they could encapsulate the lysozyme. At an optimal temperature of -20 degrees C, the polymer solution mixed rapidly with CO2, and the precipitated primary particles were sufficiently hard such that agglomeration was markedly reduced compared with higher temperatures. More uniform particles were formed by flowing CO2 at high velocity in a coaxial nozzle to mix the droplets at the CO2 vapor-liquid interface. This process offers a means to produce encapsulated proteins in poly(DL-lactide-co-glycolide) microspheres without earlier limitations of massive polymer agglomeration and limited protein solubility in organic solvents.

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A Mann Trend Test yielded a trend in increased height for 10 U.S. Presidents from 1948-1996, consistent with previous findings that height is a heuristic for dominance.

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OBJECTIVE: To determine whether chiropractic students can effectively acquire adjustive skills for the cervical spine by utilizing a Thrust in Motion Cervical (TMC) manikin and to evaluate its value as a teaching aid. A pilot study was formulated and incorporated into the skills tutorial program at Macquarie University. Centre for Chiropractic in Sydney, Australia. DESIGN AND SETTING: A prospective study was performed on chiropractic students with no prior experience in performing spinal adjustments. SUBJECTS: Twenty subjects were selected randomly from a population of 75 students about to commence their 4th-yr Master's of Chiropractic program. INTERVENTION: Students who formed the experimental group (n = 6) did not perform any thrusting maneuvers on human subjects while practicing Diversified chiropractic cervical spinal techniques. They practiced the adjustive thrust only on the TMC manikin. The control group (n = 14) learned in the established "hands-on" approach, performing thrusting maneuvers on fellow student subjects. Both groups were supervised, taught and examined in an otherwise identical fashion. RESULTS: The data indicate there is no significant difference between the examination scores of the student group that practiced on the TMC manikin (average, 2.17 points) compared with the controls (2.13 points), with a confidence interval at p = .985, assuming that 0.5 marks is clinically important in these examination results. Interexam reliability was acceptable (Pearson's r = .73) for both experimental and control examination performances. CONCLUSION: The null hypothesis is accepted, and no significant difference in student examination performance was found between those who learned thrusting on the manikin alone and those who learned on fellow students. Further, for the first time, a manikin has been shown to be effective in teaching chiropractic skills. The implications of the TMC manikin procedure will revolutionize the acquisition of motor learning skills that are essential for chiropractic skills training.

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An analysis of data for all twelve U.S. Indian Health Service areas yielded a positive Spearman's correlation coefficient for the percentage of Native American females in the labor force and the homicide rates per 100,000 population for Native American children (1 month to 14 years), supporting the hypothesis of status integration.

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Psychohistorians have uncovered a wealth of evidence suggesting that Hitler's psychopathology became projected and rationalized as social policy. Despite this cumulative evidence, no specific diagnosis has been generally accepted. The strengths and weaknesses of psychohistorical research and the ethical responsibilities involved in its use are discussed.

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The synthesis of a series of azabicyclic indole esters is described and their potency reported as 5-HT4 receptor antagonists. Optimization of the most potent compound (19) by preparing the corresponding oxazino[3,2-a]indole ester afforded 34, which had a pIC50 of 9.5 in the guinea pig distal colon longitudinal muscle myenteric plexus preparation.

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OBJECTIVES: To develop a model of cartilage degradation that (i) enables the testing of synthetic, small molecular weight matrix metalloproteinase (MMP) inhibitors as agents to prevent cartilage erosion, (ii) permits the direct assay of the principal constituents of the extracellular matrix (collagen and proteoglycan) in both the non-calcified articular cartilage and the calcified cartilage compartments, and (iii) is mediated by a chronic, granulomatous tissue that closely apposes intact articular cartilage, and in this respect resembles the pannus-cartilage junction of rheumatoid arthritis. METHODS: Femoral head cartilage was obtained from donor rats, wrapped in cotton and implanted subcutaneously into recipient animals. After a two stage papain digestion procedure, the proteoglycan and collagen contents were measured by assaying for glycosaminoglycans and hydroxyproline, respectively, in both the non-calcified cartilage that comprises the articular surface layer and the calcified cartilage compartment. The incorporation in vitro of [35S]-sulphate into glycosaminoglycans was assayed as a measure of proteoglycan biosynthesis. An osmotic minipump was cannulated to the implanted femoral head cartilage and synthetic MMP inhibitors (MI-1 and MI-2) were infused continuously over a 14 day period. RESULTS: The implanted, cotton wrapped femoral head cartilages provoked a granulomatous response that resulted in the removal of collagen and proteoglycan from the cartilage matrix. The removal of proteoglycan and collagen was exclusively from the non-calcified articular cartilage, whereas the proteoglycan and collagen content of the calcified compartment increased during the experiments. MI-1 reproducibly reduced the degradation of proteoglycan and collagen in implanted femoral head cartilage. CONCLUSIONS: We have described an in vivo model of cartilage degradation that permits the measurement of proteoglycan and collagen in both non-calcified articular cartilage and calcified cartilage compartments. The model can be used to test the effects of agents of unknown systemic bioavailability and pharmacokinetic profile by infusing them directly to the site of cartilage degradation. The removal of cartilage extracellular matrix by granulomatous tissue was inhibited by an MMP inhibitor, thus proving the involvement of this family of proteinases in cartilage catabolism in this model.

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Subjects, 98 African-American college students, were given a measure of belief in locus of control, a self-report measure of depression, and three scales from the Buss and Durkee Hostility Inventory. Depression and belief in control by powerful others correlated only for subjects with low scores on Assaultive, Verbal, and Indirect Hostility. The findings, using nonwhite subjects, replicate a previous study in which the racial composition was not indicated.

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Although Native-Americans represent a diverse population, alcoholism prevention programs need to apply general knowledge of alcohol use and misuse, rather than search for extraordinary cultural factors. Such an approach would emphasize the importance of social relationships, peer group associations, family interactions, and individual adjustment in the prevention of alcoholism among Native-Americans.

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165 college students completed a survey containing a measure of misconceptions about human aggression and attitudinal items on the death penalty from a 1985 Gallup report. Analysis did not provide strong support for the hypothesis that subjects with relatively high numbers of misconceptions about human aggression are more likely than better informed subjects to support the death penalty.

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Buss and Durkee's Hostility-Guilt Inventory was given to 23 white and 23 Native American college students. The Native American subjects scored significantly higher on the Resentment Hostility subscale while the white students scored higher on the Indirect Hostility and Guilt subscales. Implications for research are discussed.

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116 college students were given a locus of control scale and a measure of misconceptions about human aggression. A negative correlation of -.52 indicated that as feelings of mastery and control increased, belief in a human propensity for aggression decreased.

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