RESUMEN

The mono-glucose-branched cyclodextrins having an appropriate spacer between the beta-cyclodextrin and a glucose moiety were synthesized from beta-cyclodextrin and arbutin. They had the significantly high association constants for doxorubicin, the anticancer agent, in the range of 10(5)-10(6)M(-1), and worked as highly reactive glycosyl acceptors for the transglycosylation reaction by endo-beta-N-acetylglucosaminidase of Mucor hiemalis to produce sialo-complex type oligosaccharide-branched cyclodextrins in the high yields of 65-67%.

Asunto(s)

Acetilglucosaminidasa/metabolismo , Ciclodextrinas/síntesis química , Doxorrubicina/química , Portadores de Fármacos/síntesis química , Mucor/enzimología , Antineoplásicos/administración & dosificación , Sitios de Unión , Ciclodextrinas/química , Sistemas de Liberación de Medicamentos , Glucosa/química , Glicosilación , Modelos Moleculares , Oligosacáridos/química