RESUMEN
OBJECTIVES: Gender differences in patients presenting with suspected acute coronary syndromes (ACS) have not yet been fully characterized. The aim of this study was to assess gender-related disparities in clinical profiles, biomarkers and diagnoses of patients with suspected ACS. METHODS: This single-centre, prospective cohort study included 377 consecutive patients presenting with suspected ACS to the emergency department. Suspected ACS was defined as a request for conventional troponin T (c-cTnT) measurements on clinical grounds. RESULTS: Women were older than men (p = 0.004), and had a lower prevalence of known coronary artery and peripheral vascular disease (p < 0.05). c-cTnT was positive in 8% of female and in 14% of male patients (p = 0.16), TIMI risk score and cardiac biomarkers including c-cTnT, hs-cTnT, myoglobin, creatine kinase, N-terminal pro-brain natriuretic peptide, myeloid-related protein 8/14 and pregnancy-associated plasma protein A were lower in women (p < 0.05). Women were less frequently diagnosed with ACS (30 vs. 51%), and were not referred for urgent coronary angiography as often as men (p < 0.001). In multivariate analysis, female gender was associated with a lower referral for coronary angiography (HR 0.41, 95% CI 0.23-0.78, p = 0.006). CONCLUSIONS: In patients with suspected ACS, women presented with different biomarker profiles, and were less often diagnosed with ACS and referred to coronary angiography.
Asunto(s)
Síndrome Coronario Agudo/sangre , Síndrome Coronario Agudo/diagnóstico , Factores Sexuales , Anciano , Biomarcadores/sangre , Angiografía Coronaria , Creatina Quinasa/sangre , Servicio de Urgencia en Hospital , Femenino , Alemania , Humanos , Modelos Logísticos , Masculino , Persona de Mediana Edad , Análisis Multivariante , Mioglobina/sangre , Péptido Natriurético Encefálico/sangre , Dimensión del Dolor/estadística & datos numéricos , Estudios Prospectivos , Troponina T/sangreRESUMEN
Our descriptive technical report on 7 children describes the microsurgical laser scalpel as an useful tool for removal of firm and soft lesions from a variety of delicate tissues. It combines precise atraumatic tissue dissection with immediate hemostasis while having no adverse side effects on adjacent and neighbouring tissues even through a limited surgical access.
Asunto(s)
Terapia por Láser/instrumentación , Microcirugia/instrumentación , Neurocirugia/instrumentación , Pediatría/instrumentación , Adolescente , Niño , Preescolar , Femenino , Humanos , Lactante , MasculinoRESUMEN
Two isolates from the cervical canal of clinically normal sows were indistinguishable from Corynebacterium pseudotuberculosis in their biochemical properties and genetic homology by DNA-DNA hybridisation. Furthermore, three sheep inoculated with one of the isolates developed typical lesions of caseous lymphadenitis and gave antibody responses specifically to C pseudotuberculosis.
Asunto(s)
Cuello del Útero/microbiología , Corynebacterium pseudotuberculosis/aislamiento & purificación , Porcinos/microbiología , Animales , Infecciones por Corynebacterium/microbiología , Infecciones por Corynebacterium/veterinaria , Corynebacterium pseudotuberculosis/patogenicidad , Ensayo de Inmunoadsorción Enzimática/veterinaria , Femenino , Hibridación de Ácido Nucleico , Ovinos , Enfermedades de las Ovejas/microbiología , Enfermedades de los Porcinos/microbiología , VirulenciaRESUMEN
Microcirculatory effects of intravenous administrations in the appropriate doses of phenoxybenzamine (POBA), phentolamine (PTA), nicotinic acid (NAc), trimetazidine (TMZ), dilazep (DZ), cepharanthine (CT), alpha-tocopheryl acetate (TP-A), and alpha-tocopheryl nicotinate (TP-N) as vasodilator agents were investigated in the subcutaneous tissue within a transparent ear chamber of the normal conscious rabbit. The intra-vital microscopic findings obtained following administration of the drugs were as follows: POBA, a marked and long-lasting vasodilatation without vasomotion (more than 1 hour); PTA, a quite brief vasodilatation followed by a marked and long-lasting vasoconstriction without vasomotion (more than 1 hour); NAc, a short-lasting vasodilatation with slightly blunted vasomotion (less than 10 minutes); TMZ, DZ, CT, TP-A, and TP-N, a similar notable and transient vasodilatation with vasomotion (about 1 hour or more). Some physiological implications on the microcirculatory changes induced by administrations of the drugs were discussed especially in relation to the significance of sustaining the rhythmic fluctuations of blood flow due to vasomotion.
Asunto(s)
Piel/irrigación sanguínea , Vasodilatadores/farmacología , Animales , Dilazep/farmacología , Femenino , Masculino , Microcirculación/efectos de los fármacos , Niacina , Ácidos Nicotínicos/farmacología , Fenoxibenzamina/farmacología , Fentolamina/análogos & derivados , Fentolamina/farmacología , Conejos , Trimetazidina/farmacología , Vitamina E/farmacologíaRESUMEN
Effects of intracerebral (i.c.) administration of metaraminol (MA) on brain monoamine in mice were studied. The results were as follows: MA, dopamine (DA), noradrenaline (NA) and 5-hydroxytryptamine (5-HT) were separated with phosphate buffer using a phosphorylated cellulose column (1X11 cm, 9 ml, Lot No. 2809). When MA was i.c. injected into mice, fluorescence of MA at 275/305 nm decreased in proportion to the time course and remained even at 12 hr after injection. Thirty min after MA in doses of either 40 or 80 microgram, a significant decrease of DA as compared with that of saline-treated group occurred and MA, in doses of 40, 80 and 160 microgram produced a significant decrease of NA and 5-HT. Thirty min after 160 microgram of MA, there was no significant difference in DA. Three hr after MA, DA levels significantly decreased, and 168 hr after were restored to the levels of the saline-treated group. Thirty min after MA, NA and 5-HT signficantly decreased compared with those of the saline-treated group and recovery took place 48 hr and 168 hr after respectively. It was concluded that MA depletes not only NA but also DA and 5-HT in the mouse brain.