RESUMEN
Lipid accumulation in the vessel wall and tunica intima vasorum pathological changes are important factors in the development of atherosclerosis, which are closely related with hemodynamics. In this paper, we established a model of local low shear stress in rabbits using carotid artery cannula and a high cholesterol diet for 2 weeks, 4 weeks and 8 weeks. The effects of Shenlian extract on blood flow, vascular pathology formation and lipid metabolism were assessed by electromagnetic blood flow meter and hematoxylin-eosin staining of the proximal end in carotid artery at different times. The results demonstrate that the relationship between blood flow and shear stress for control, atorvastatin, Shenlian extract high-dose, Shenlian extract middle-dose, and Shenlian extract low-dose were linearly related. The blood flow and the shear stress of proximal end in carotid artery of Shenlian extract (1.12, 2.24, 4.48 g x kg(-1)), and atorvastatin (4.7 x 10(-4) g x kg(-1)) were significantly (P < 0.05)increased compared with the control. Plasma total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) ,and high density lipoprotein cholesterol (HDL-C) were markedly decreased with the increasing of dose and time. This study is the first to prove that the inhibition of Shenlian extract on low shear stress (LSS) induces rabbits carotid atherosclerosis with increasing blood flow and decreasing lipids and vessel pathological changes.
Asunto(s)
Animales , Humanos , Masculino , Conejos , Fenómenos Biomecánicos , Velocidad del Flujo Sanguíneo , Arterias Carótidas , Química , Patología , Enfermedades de las Arterias Carótidas , Quimioterapia , Patología , Medicamentos Herbarios Chinos , Estrés MecánicoRESUMEN
The definition and content of opposite points is updated, and renovation of acupuncture teaching is explored in this article. Opposite points interconnect meridians and acupoints. Location of one point reminds that of the other in pairs. When manipulating, point-to-point puncture from two opposite sides or penetrating method from one side are both applicable. It has the advantages of less point selection and regulating yin and yang. Its application in teaching of meridians, acupoints, acupuncture technique and treatment may bring enthusiasm into the study as well as improve the level of teaching.