RESUMEN

Strain FIM06054 was isolated from a marine sponge sample collected from the East China Sea and was characterised as a strain of Verrucosispora genus on the basis of its 16S rRNA gene sequence. One new compound, FW054-1 (1), together with a known aminofuran compound proximicin A (2), was isolated from the culture broth of Verrucosispora sp. FIM06054. Their structures were elucidated on the basis of spectral analysis. 1 and 2 showed antiproliferative activity against several human tumour cell lines.

Asunto(s)

Antineoplásicos/aislamiento & purificación , Antineoplásicos/farmacología , Micromonosporaceae/química , Netropsina/análogos & derivados , Poríferos/química , Ribosa/análogos & derivados , Ribosa/aislamiento & purificación , Ribosa/farmacología , Animales , Antineoplásicos/química , Ensayos de Selección de Medicamentos Antitumorales , Humanos , Biología Marina , Netropsina/química , Netropsina/aislamiento & purificación , Netropsina/farmacología , Resonancia Magnética Nuclear Biomolecular , ARN Ribosómico 16S/genética , Ribosa/química