RESUMEN

F2-isoprostanes are prostaglandin-like compounds derived from free radical-catalysed peroxidation of arachidonic acid. Peroxidation of eicosapentaenoic acid produces F3-isoprostanes, whereas peroxidation of docosahexaenoic acid would give F4-isoprostanes. This study demonstrates the presence of esterified F4-isoprostanes in human brain and shows that levels are elevated in certain brain cortex regions in Alzheimer's disease. Our data with Alzheimer's disease suggest that analysis of F4-isoprostanes will provide new opportunities to study lipid peroxidation in the neurodegenerative diseases.

Asunto(s)

Enfermedad de Alzheimer/metabolismo , Química Encefálica , Ácidos Docosahexaenoicos/análisis , Ácido Eicosapentaenoico/análisis , Ácido Araquidónico/análisis , Ácido Araquidónico/química , Biomarcadores , Corteza Cerebral/química , Ácidos Docosahexaenoicos/química , Ácido Eicosapentaenoico/química , Ésteres/análisis , Cromatografía de Gases y Espectrometría de Masas , Humanos , Peroxidación de Lípido/fisiología , Lípidos/análisis