RESUMEN

In addition to its role in erythropoiesis, erythropoietin (Epo) plays a role in tissue protection, which includes cardioprotective, nephroprotective and neuroprotective effects. The presence of Epo and its receptor (Epo-R) in pulmonary tissue also suggests a cytoprotective effect of Epo in the lung. Our project aims to document this role in a murine model under-expressing Epo. The obtained results will lead to a better understanding of the cytoprotective effects of Epo and will also give an appreciation of its beneficial effects in cases of lung injury.

Asunto(s)

Lesión Pulmonar Aguda/patología , Citoprotección , Eritropoyetina/farmacología , Eritropoyetina/fisiología , Riñón , Animales , Citoprotección/efectos de los fármacos , Citoprotección/genética , Modelos Animales de Enfermedad , Eritropoyetina/genética , Hematopoyesis/efectos de los fármacos , Hematopoyesis/genética , Humanos , Riñón/efectos de los fármacos , Riñón/patología , Pulmón/efectos de los fármacos , Pulmón/patología , Pulmón/fisiología , Ratones