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Outrage of modesty (OOM) is considered a serious crime in Singapore and offenders are often charged with a period of imprisonment with or without a fine and caning. Previous studies have indicated that non-violent sexual offenders tend to have a socially inhibited personality. No published study has yet been conducted to investigate the personality of OOM offenders. The purpose of the current study was to assess the personality of males charged with outrage of modesty and compare them to a group of males charged with theft using the 16 Personality Factors questionnaire (16PF; Cattell, Eber, and Tatsuoka, 1970). Participants were selected over a two-year study period from a cohort of prisoners serving sentence at Changi Prison. A total of 30 OOM and 22 theft offenders completed the 16PF. All OOM subjects had been charged for molesting an adult female. Unexpectedly, planned comparisons revealed that OOM subjects had marginally higher scores on Factor H (boldness) compared to theft subjects. Exploratory analyses revealed no other significant differences between OOM and theft subjects. Implications of findings and limitations of the study are discussed.

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Outrage of modesty (OOM) offenders cause considerable annoyance and distress to their victims. The offending behaviours include touching, grabbing or fondling of erogenous or non-erogenous parts of the victim's body. The purpose of this study is to examine a prison cohort of OOM offenders and to compare them with a group of OOM offenders who had been remanded in a state mental hospital. All prisoners serving sentence over a two-year study period were interviewed. They were of similar mean age to the hospital cohort but were better educated, more likely to be married and most were working. Victims tended to be young females with an average age of 19 years. Psychotic disorders were rarely present, although 15% had a dissocial personality disorder. Those with previous OOM convictions were likely to have had past psychiatric consultations and were more likely to be unmarried. However, there were no statistically significant differences between convicted first-time offenders and repeat offenders with respect to age, educational level, nature of offences and alcohol consumption. The prisoners were less inclined to commit their offences in the mornings. Breasts and genitalia were the favoured targets for molest action, irrespective of time or place or whether the offence was committed by a first or repeat offender. The offences were often committed along staircases, corridors and in crowded public places.

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To gain better understanding into the causes of molesting behaviour in males, we examined a prison cohort of molesters and compared them with a control group comprising thieves. The molesters were older, had attained a higher educational level and were more likely to be married. They had their initial sexual intercourse at an older age but tended to have multiple sexual relationships and were less likely to report having viewed pornographic material. Three months prior to committing their offences, molesters seemed to engage in less sexual activity. The implications are that molesters had a need for more explicit sexual contact but were unable to sustain ongoing, stable, intimate sexual relationships.

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UNLABELLED: BACKGROUND OF STUDY: Three hundred and sixty three subjects from various civil service organisations were administered the SCOPE-i (Stress, Coping and Personality Inventory) as part of the Institute of Mental Health's efforts to promote mental health in the workplace. AIM OF STUDY: This study examines the relationship between stress-related factors and absenteeism. Absenteeism is measured by the number of days of medical leave taken (MC) and self-report of minor illnesses (MI) which are not severe enough to warrant the coverage of a medical certificate. RESULTS: In this study, we are interested in the differences between MI and MC, and their respective relationships with stress-related factors. We hypothesised that MI, rather than MC, is more related to poor workplace conditions. The findings of this study support this hypothesis. Thus if workplace environment is stressful, people are still likely to come to work despite their illness. An interesting observation in this study is the different ways in which environmental stressors and psychosocial aspects of the workplace environment affect the MC variable. Individuals are more likely to take MC when the environmental stressors are high (i.e., poor lighting, uncomfortable temperatures, etc) as compared to poor psychosocial environmental conditions (e.g., work overload, high organisational tension, career limitations and high personal constraints). On the other hand, when faced with poor psychosocial environmental conditions, MI increases instead of MC. CONCLUSION: These findings have implications on the types of changes in a workplace which employers should make in order to decrease MC and improve physical well-being. In addition, the study shows the usefulness of MI in future studies as a dependent variable.

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PURPOSE: To compare the efficacy and toxicity profiles of a combination of fluorouracil (5-FU) and recombinant human interferon alfa-2a ([IFN alpha 2a] Roferon-A; Hoffmann-LaRoche, Basel, Switzerland) versus 5-FU alone in the treatment of advanced colorectal cancer (ACC). PATIENTS AND METHODS: A total of 245 previously untreated ACC patients were randomized to receive either IFN alpha 2a (9 million IU) subcutaneously (SC) three times weekly with 5-FU (750 mg/m2/d) by continuous intravenous (CIV) infusion on days 1 to 5 and then, after a 1-week hiatus, as a weekly IV bolus at the same dose (IFN/ 5-FU), or 5-FU alone at the same dose schedule (5-FU). RESULTS: There were no significant differences between IFN/5-FU and 5-FU alone in the overall response rate (24% v 17%, P = .2), duration of response (median, 6.4 v 8.1 months), time to response (plateau at 3 months), time to progressive disease ([PD] median, 4.8 v 4.9 months), or survival duration (median, 13.9 v 13.2 months). Toxicity profiles were not statistically different except for constitutional symptoms, which were more frequent and more severe with IFN/5-FU. More patients interrupted treatment for adverse events (AEs) with IFN/ 5-FU (34%) than with 5-FU alone (21%) (P = .03). The number of deaths (mostly unrelated to drug treatment) during the study (8%) was similar with both regimens. CONCLUSION: The combination IFN/5-FU produced a response rate, response duration, and survival duration similar to that of 5-FU alone. The addition of IFN to 5-FU in the doses and schedules used in this study did not provide any further benefit over 5-FU alone and cannot be recommended for patients with metastatic ACC. This study confirms the value of large prospective randomized clinical trials to determine the clinical value of regimens that emerge from smaller single-center phase II studies.

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A rapid and inexpensive enzyme inhibition procedure has been developed for the assay of methotrexate in biological fluids. The method achieves a high degree of sensitivity, reproducibility, and specificity. No prior separation procedures are required, and there is no cross-reaction with metabolites of methotrexate or other substances such as folinic acid, which is often given concurrently with methotrexate. Results are in good agreement with those given by the more expensive enzyme multiplied immunoassay technique. The new method is 30 times more sensitive than the enzyme multiplied immunoassay technique, being capable of determining concentrations as low as 1.0 X 10(-8) M (4.5 ng/ml), a distinct advantage over the enzyme multiplied immunoassay technique, since it may be successfully employed in conducting clinical pharmacokinetic studies.

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The serum concentrations of alpha-1-acid glycoprotein, haptoglobin and alpha-1-antitrypsin have been estimated serially in eight patients with malignant tumours of bone and soft tissue, who received a total of thirty-four intravenous infusions of high-dose methotrexate. The serum glycoprotein levels taken before the first drug exposure did not relate with the prognosis of these patients. A tumour mass (40 mm) did not influence the serum levels of these glycoproteins. The presence of a pleural effusion was associated with increased serum levels of these glycoproteins. These assays appear to be of no value in monitoring the course of the disease in this group of cancer patients.

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The serum concentrations of six glycoproteins (alpha 1-acid glycoprotein, AGP; haptoglobin, Hp; alpha 1-antitrypsin, AT; ceruloplasmin, Cp; prealbumin, PALB; and alpha 2-macroglobulin, MACRO) have been estimated serially in nine advanced breast cancer patients who received a total of 24 intravenous infusions of methotrexate (MTX). The serum glycoprotein levels taken before the first drug exposure did not relate with the prognosis of these patients. In eight patients, constantly high or rising levels of AGP, Hp and AT during consecutive infusions of the drug were associated with continued metastatic disease. A transient tumour regression occurred in one patient which correlated with falling serum levels of these proteins into the normal range. The serum levels of Cp, PALB and MACRO did not correlate with the clinical status of these patients during treatment. Possible factors which may influence the serum levels of these glycoproteins in cancer patients during therapy are discussed.

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