RESUMEN

The synthetic progress of bioactive 2,7'-cyclolignans is reviewed. After a short introduction to biosynthesis and chemoenzymatic synthesis, the chemical synthesis of various aryltetralin, dihydronaphthalene and 7'-arylnaphthalene-types of these lignans is demonstrated. Notably, newly developed methods, such as Pd-catalyzed C-H arylation, organocatalysis and photocatalysis under visible-light, are discussed during the construction of their skeleton. These efforts will stimulate further development of novel synthetic strategies for this kind of natural product with important biological activities.

Asunto(s)

Productos Biológicos/síntesis química , Lignanos/síntesis química , Productos Biológicos/química , Catálisis , Luz , Lignanos/química , Estructura Molecular , Paladio/química , Estereoisomerismo