1.
Chem Commun (Camb)
; 54(73): 10316-10319, 2018 Sep 11.
Artículo
en Inglés
| MEDLINE
| ID: mdl-30140835
RESUMEN
The first asymmetric total synthesis of pleurospiroketals A and B has been accomplished in 16 steps from 5-methyl-5-hexenoic acid. Key features of the synthesis are the highly syn-selective Evans aldol reaction, ring-closing metathesis, highly diastereoselective dihydroxylation and acid-mediated spiroketalization.