RESUMEN

Solid-pseudopapillary neoplasms (SPN) are rare pancreatic tumors. The etiology of SPN involves mutations in the gene that encodes ß-catenin (CTNNB1). We herein report the case of a 23-year-old woman with a large SPN with proliferating tumor cells that displayed both solid and pseudo-papillary patterns. The simultaneous nuclear accumulation and loss of membrane localization of ß-catenin and E-cadherin was specifically observed in the tumor cells. Further, the tumor cells were shown to harbor a missense mutation in exon 3 of CTNNB1. We also present a review of the literature describing the clustering of CTNNB1 mutations in patients with SPN.

Asunto(s)

Carcinoma Papilar/genética , Carcinoma Papilar/metabolismo , Neoplasias Pancreáticas/genética , Neoplasias Pancreáticas/metabolismo , beta Catenina/genética , beta Catenina/metabolismo , Cadherinas/metabolismo , Carcinoma Papilar/diagnóstico , Núcleo Celular/metabolismo , Análisis Mutacional de ADN , Femenino , Humanos , Mutación , Neoplasias Pancreáticas/diagnóstico , Adulto Joven