RESUMEN
Hypoxia leads to increased red blood cells and blood viscosity at high altitude while moderate trauma increases coagulation in blood. Under the above-mentioned conditions, venous sinus thrombosis is more likely to occur. A patient suffering bilateral acetabular fractures together with the gradual disturbance of consciousness was admitted to our hospital. Though computed tomography arteriogram (CTA) of the brain displayed normal blood vessels; bilateral thalamus and brainstem infarction were found on head computed tomography (CT) and Galen vein thrombosis on cerebral computed tomography venography (CTV). Dehydration and tracheotomy were immediately conducted with antiplatelet, anticoagulant and neurotrophic medicine administered to the patient. After three days' treatment, the patient's consciousness gradually improved and eventually became clear enough to leave the hospital. On follow-up, no dysfunction was documented.
Asunto(s)
Acetábulo/lesiones , Venas Cerebrales , Fracturas Óseas/complicaciones , Trombosis de la Vena/etiología , Humanos , Masculino , Persona de Mediana Edad , Tibet , Tomografía Computarizada por Rayos X , Trombosis de la Vena/diagnóstico por imagenRESUMEN
To establish a rat model of an open craniocerebral injury at simulated high altitude and to examine the characteristics of this model. Rats were divided randomly into a normobaric group and a high-altitude group and their corresponding control groups. A rat model of an open craniocerebral injury was established with a nail gun shot. Simulated high-altitude conditions were established with a hypobaric chamber at 0.6 ATA to mimic pressure at an altitude of 4000 m. Mortality, brain water content (BWC), Evans blue content, pathology, regional cerebral blood flow (rCBF), partial pressure of brain tissue oxygen (PbtO2), and brainstem auditory-evoked potential were observed after injury. The mortality of the high-altitude group was significantly greater than that of the normobaric group within 72 h after injury (P<0.05). BWC and Evans blue content increased by 48 h after injury (P<0.05); pathological changes in damaged brains were more serious. In contrast, rCBF and PbtO2 had decreased markedly by 72 h (P<0.01); brainstem auditory-evoked potential values were significantly prolonged (P<0.05). Moreover, an inverse correlation between rCBF and BWC and a positive correlation between rCBF and PbtO2 were found. The rat model of an open craniocerebral injury at simulated high altitude can be established successfully using a nail gun shot and a hypobaric chamber. The injury characteristics at high altitude were more serious, rapid, and prolonged than those in the normobaric group.
Asunto(s)
Modelos Animales de Enfermedad , Traumatismos Penetrantes de la Cabeza/patología , Traumatismos Penetrantes de la Cabeza/fisiopatología , Altitud , Animales , Presión Atmosférica , Encéfalo/irrigación sanguínea , Potenciales Evocados Auditivos del Tronco Encefálico , Traumatismos Penetrantes de la Cabeza/mortalidad , Masculino , Ratas , Ratas WistarRESUMEN
OBJECTIVE: To study the methods for intraoperative treatment of the cyst contents in patients with abdominal echinococcosis. METHOD: Sixty-nine cases of abdominal echinococcosis were reviewed for intraoperative disposal of the cyst contents using 5% formaldehyde (group A, 33 cases) or 25% NaCl solution (group B, 36 cases), and the effects and incidence of complications were compared. RESULTS: No relapse occurred in 33 cases with 5% formaldehyde treatment of the cyst contents, but postoperative intestinal fistula took place in 8 cases. In 36 cases with 25% NaCl treatment of the cyst contents, relapse occurred in one case postoperatively but no complications were seen in other patients. CONCLUSION: Treatment of the cyst contents with 5% formaldehyde may lead to intestinal fistula, and 25% NaCl solution may give rise to the risk of recurrence, so that both methods need improvement.