RESUMEN
A new rhodamine-6G-based chemosensor X was designed and synthesized for the colorimetric and fluorometric detection of Hg2+. The chemosensor X responsed to Hg2+ had good sensitivity, high selectivity and excellent reversibility in HEPES buffer (10â¯mM, pHâ¯7.4)/CH3CN (40:60, V/V). The recognition mechanism of X toward Hg2+ was evaluated by Job's plot, IR and MS. Meanwhile, X-Hg2+ fluorescence lifetime was also measured. It was interesting that X displayed favorable reversibility to form an "off-on-off" type signaling behavior with the Hg2+-induced emission spectra being quenched by I-. Furthermore, it could be applied as a molecular logic gate and test strips based on X exhibited a good reversibility selectivity to Hg2+.
RESUMEN
The Hedgehog signaling pathway plays a key role in mammalian embryogenesis, while it is quiescent in adult tissues. The aberrant activation of Hedgehog signaling pathway has been linked to multiple types of malignant tumors, which makes it an attractive target for cancer therapy in recent years. Up to now, two Hedgehog inhibitors (vismodegib and sonidegib) have been proved by FDA for the treatment of tumors. However, drug resistance and severe adverse reactions represent the problems in their clinical application. Novel inhibitors targeting Smo, such as taladegib, NVP-LEQ506, MRT-92, and downstream or upstream of Smo receptor such as Shh ligand and Gli have been developed to overcome the drug resistance and adverse reactions. The current Hedgehog inhibitors are used for treatment of basal cell carcinoma only, while many ongoing clinical trials are conducted to investigate the antitumor effect of Hedgehog inhibitors in other malignancies. Here we reviewed the research progress of the new anticancer drugs targeting the Hedgehog signaling pathway and their prospect in variety of cancers therapy.