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Objective To study the effect of escin on proteinuria and renal function of BXSB mice. Methods BXSB mice were divided randomly into group A (control group), B (steroid treatment group), C(steroid combined with high-dose esein treatment group) and D (streroid combined with low-doze escin group). The proteinufia and renal function were detected by albustix and automatic biochemistry analyzer after a month's treatment. Results Group C reduced the level of proteinuria and parameters of renal function (BUN and Cr) significantly when compared with other three groups (P<0.05). Conclusion Escin can reduce the level of proteinuria and protect renal function of BXSB mice.
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Objective To observe the clinical effect on hip involvement on patients with ankylosing spondylitis by hip joint fluid relax operation.Methods 112 patients with ankylosing spondylitis and hip involvement were selected from the Department of Rheumatology and Immunology,Union Hospital of Tongji Medical College,Huazhong University of Science and Technology from 2003 to 2004.The patients were randomly assigned into curative group of 60 patients and control group of 52 patients.The patients in both groups took medication,and those in the curative group were treated with hip joint 'fluid relax operation besides the drug treatment.Compare the change of the following index(the hip joint function,CT staging of hip joint involvement,VAS point,erythrocyte sedimentation and plasma reactive protein)assessment between the two groups before treatment and after treatment of one year and two years.Results Score of hip joint function and VAS point were obviously higher before treatment than after treatment of one year and two years in both groups(P