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Objective To evaluate the effects of acupuncture combined with lifestyle modification for essential hypertension by Meta-analysis. Methods Clinical randomized controlled trial literature about acupuncture combined with lifestyle modification for essential hypertension in CNKI, WanFang Data, CBM, VIP, PubMed, Embase, and Web of Science since establishment to February 20, 2017 were retrieved. Data extraction and quality assessment of studies were conducted by two researchers independently, and the Meta-analysis was performed by the software of RevMan5.3. Results 5 articles involving 467 patients were included. The results of Meta-analysis showed that acupuncture combined with lifestyle modification had more significant effect than lifestyle modification alone in lowing SBP [SMD=-1.52(-2.40,-0.64)], in lowing DBP [SMD=-1.02(-2.01,-0.03)], total effective rates [RR=1.27(1.13, 1.43)]. Conclusion Compared with lifestyle modification alone, acupuncture combined with lifestyle modification have significant effects for patients with essential hypertension, but because of the fewer studies included, bigger heterogeneity between studies and the lower quality of included studies still exist, the results should be further verified, and clinical applications should be treated with caution.
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Objective To evaluate the dietary arsenic intake level among residents in Hangzhou city,and to provide scientific basis for further food safety assessment.Methods A stratified multi -stage cluster sampling method was performed,and a total of 1 744 subjects were enrolled.Total diet survey was conducted to collect food consumption data through both food -weighting and recording during 3 consecutive days.Representative mixed food samples were prepared for total arsenic (tAs)detecting by using inductively coupled plasma -mass spectrometry (ICP -MS).Daily tAs and weekly presumptive inorganic arsenic (p -inAs)intakes were calculated and compared with corresponding tolerable limit values.Results The medians of dietary tAs and p -inAs intakes were 1 .4 μg/kgbw/d and 3.0 μg/kgbw/week,which accounted for 2.8% and 20.2% of corresponding former TDMI /PTWI,respectively.The tAs and p -inAs intake (1 .6 μg/kg·bw/d and 3.5 μg/kg·bw/week,respectively)in the age group of <1 8 years were significantly higher than that of other age groups (Z =-7.577 ~-2.91 7,P <0.01 ).The mainly source of individual dietary arsenic intakes was cereal foods.Conclusion The dietary intake of tAs and p -inAs are safe,but more attention should be paid to juveniles for the dietary intakes of tAs and p -inAs .
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Objective To investigate the relationship between apolipoprotein E (APOE) genotype and onset of hypertensive intracerebral hemorrhage (HICH). Methods One hundred and twenty-eight patients with HICH,admitted to our hospital from September 2007 to December 2010,and 84 healthy controls clinically flee from neurology disease were chosen in our study.A POE genotype was determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP); the distribution ofAPOE genotype and allele fiequency between the 2 groups were compared; the age of onset,gender,blood pressure,blood fat,bleeding part and size of haematoma in patients with different APOE genotype were further studied. Results The subjects with smoking hobby,diabetes history and higher concentrations of TC and LDL-C in the HICH group were obviously more than those in the control group (P＜0.05).As compared with those in the controls,the distributions of the APOEε3/4 and APOEε4 in the HICH group were significantly higher, and the distributions of the APOEε3/3 and APOEε3 in the HICH group were significantly lower (P＜0.05). The APOEε3/4 and APOEε4 carriers enjoyed higher percentages of onset age less than 45 years and superficial haematoma than A POEε3/3 and the A POEε3 carriers. The onset systolic blood pressure in APOEε3/4 and APOEε4 carriers was obviously lower than that in A POEε3/3 and A POEε3 carriers (P＜0.05). The plasma concentrations of LDL-C and TC in APOEε3/4 and APOEε4 carriers was significantly higher than those in APOEε3/3 and APOEε3 carriers (P＜0.05). Conclusion The APOE genotype influences the onset of HICH, and its influence factors included onset age, blood pressure,blood fat and bleeding part,which may concern with the cerebral artherosclerosis or amyloidosis.