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Despite the significant advancements facilitated by previous research in introducing a plethora of retinal biomarkers, there is a lack of research addressing the clinical need for quantifying different biomarkers and prioritizing their importance for guiding clinical decision making in the context of retinal diseases. To address this issue, our study introduces a novel framework for quantifying biomarkers derived from optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) images in retinal diseases. We extract 452 feature parameters from five feature types, including local binary patterns (LBP) features of OCT and OCTA, capillary and large vessel features, and the foveal avascular zone (FAZ) feature. Leveraging this extensive feature set, we construct a classification model using a statistically relevant p value for feature selection to predict retinal diseases. We obtain a high accuracy of 0.912 and F1-score of 0.906 in the task of disease classification using this framework. We find that OCT and OCTA's LBP features provide a significant contribution of 77.12% to the significance of biomarkers in predicting retinal diseases, suggesting their potential as latent indicators for clinical diagnosis. This study employs a quantitative analysis framework to identify potential biomarkers for retinal diseases in OCT and OCTA images. Our findings suggest that LBP parameters, skewness and kurtosis values of capillary, the maximum, mean, median, and standard deviation of large vessel, as well as the eccentricity, compactness, flatness, and anisotropy index of FAZ, may serve as significant indicators of retinal conditions.

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BACKGROUND: Left ventricular pressure-volume (LV-PV) loops provide comprehensive characterization of cardiovascular system in both health and disease, which are the essential element of the hemodynamic evaluation of heart failure (HF). This study attempts to achieve more detailed HF classifications by non-invasive LV-PV loops from echocardiography and analyzes contribution of parameters to HF classifications. METHODS: Firstly, non-invasive PV loops are established by time-varying elastance model where LV volume curves were extracted from apical-four-chambers view of echocardiographic videos. Then, 16 parameters related to cardiac structure and functions are automatically acquired from PV loops. Next, we applied six machine learning (ML) methods to divide four categories. On this premise, we choose the best performing classifier among machine learning approaches for feature ranking. Finally, we compare the contributions of different parameters to HF classifications. RESULTS: By the experimental, the PV loops were successfully acquired in 1076 cases. When single left ventricular ejection fraction (LVEF) is used for HF classifications, the accuracy of the model is 91.67%. When added parameters extracted from ML-derived LV-PV loops, the classification accuracy is 96.57%, which improved by 5.1%. Especially, our parameters have a great improvement in the classification of non-HF controls and heart failure with preserved ejection fraction (HFpEF). CONCLUSIONS: We successfully presented the classification of HF by machine derived non-invasive LV-PV loops, which has the potential to improve the diagnosis and management of heart failure in clinic. Moreover, ventriculo-arterial (VA) coupling and ventricular efficiency were demonstrated important factors for ML-based HF classification model besides LVEF.

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OBJECTIVE: To facilitate the analysis and diagnosis of X-ray coronary angiography in interventional surgery, it is necessary to extract vessel from X-ray coronary angiography. However, vessel images of angiography suffer from low quality with large artefacts, which challenges the existing vascular technology. METHODS: In this paper, we propose a ávessel framework to detect vessels and segment vessels in angiographic vessel data. In this framework, we develop a new matrix decomposition model with gradient sparse in the tensor representation. Then, the energy function with the input of the hierarchical vessel is used in vessel detection and vessel segmentation. RESULTS: Through experiments conducted on angiographic data, we have demonstrated the good performance of the proposed method in removing background structure. CONCLUSION: We evaluated our method for vessel detection and segmentation in different clinical settings, including LAO/RAO with cranial and caudal angulation, and showed its competitive results compared with eight state-of-the-art methods in terms of extensive qualitative and quantitative evaluation. SIGNIFICANCE: Our method can remove a large number of background artefacts and obtain a better vascular structure, which has contributed to the clinical diagnosis of coronary artery diseases.

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To solve the 2 ? phase ambiguity for phase-resolved Doppler images in Doppler optical coherence tomography, we present a modified network programming technique for the first time to the best of our knowledge. The proposed method assumes that error of the discrete derivatives between unwrapped phase image and wrapped phase image can be arbitrary values instead of integer-multiple of 2 ? , which makes the real-phase restoration accurate and robust against noise. We compared our proposed method with the network programming method. Parameters including root-mean-square-error and noise amplification degree were adopted for comparison. The experimental study on simulated images, phantom, and real-vessel OCT images were performed. The proposed method consistently achieves optimal results.

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Phase image in Fourier domain Doppler optical coherence tomography offers additional flow information of investigated samples, which provides valuable evidence towards accurate medical diagnosis. High quality phase images are thus desirable. We propose a noise reduction method for phase images by combining a synthetic noise estimation criteria based on local noise estimator (LNE) and distance median value (DMV) with anisotropic diffusion model. By identifying noise and signal pixels accurately and diffusing them with different coefficients respectively and adaptive iteration steps, we demonstrated the effectiveness of our proposed method in both phantom and mouse artery images. Comparison with other methods such as filtering method (mean, median filtering), wavelet method, probabilistic method and partial differential equation based methods in terms of peak signal-to-noise ratio (PSNR), equivalent number of looks (ENL) and contrast-to-noise ratio (CNR) showed the advantages of our method in reserving image energy and removing noise.