RESUMEN
An association between depression and altered immune and hormonal systems has been suggested by the results of many studies. In the present study we carried out immune and hormonal measurements in 40 non-medicated, ambulatory adult patients with depression determined by CID-10 criteria and compared with 34 healthy nondepressed subjects. The severity of the condition was determined with the Hamilton Depression Rating Scale. Of 40 depressed patients, 31 had very severe and 9 severe or moderate depression, 29 (72.5%) were females and 11 (27.5%) were males (2.6:1 ratio). The results revealed a significant reduction of albumin and elevation of alpha-1, alpha-2 and beta-globulins, and soluble IL-2 receptor in patients with depression compared to the values obtained for nondepressed subjects (P<0.05). The decrease lymphocyte proliferation in response to a mitogen was significantly lower in severely or moderately depressed patients when compared to control (P<0.05). These data confirm the immunological disturbance of acute phase proteins and cellular immune response in patients with depression. Other results may be explained by a variety of interacting factors such as number of patients, age, sex, and the nature, severity and/or duration of depression. Thus, the data obtained should be interpreted with caution and the precise clinical relevance of these findings requires further investigation.
Asunto(s)
Citocinas/sangre , Depresión/inmunología , Depresión/metabolismo , Hormonas/sangre , Adolescente , Adulto , Proteínas Sanguíneas/metabolismo , División Celular , Citocinas/metabolismo , Femenino , Hormonas/metabolismo , Humanos , Linfocitos/citología , Masculino , Persona de Mediana Edad , Receptores de Interleucina-2/sangre , Receptores de Interleucina-2/metabolismo , Albúmina Sérica/metabolismo , Seroglobulinas/metabolismo , Índice de Severidad de la EnfermedadRESUMEN
An association between depression and altered immune and hormonal systems has been suggested by the results of many studies. In the present study we carried out immune and hormonal measurements in 40 non-medicated, ambulatory adult patients with depression determined by CID-10 criteria and compared with 34 healthy nondepressed subjects. The severity of the condition was determined with the Hamilton Depression Rating Scale. Of 40 depressed patients, 31 had very severe and 9 severe or moderate depression, 29 (72.5 percent) were females and 11 (27.5 percent) were males (2.6:1 ratio). The results revealed a significant reduction of albumin and elevation of alpha-1, alpha-2 and beta-globulins, and soluble IL-2 receptor in patients with depression compared to the values obtained for nondepressed subjects (P<0.05). The decrease lymphocyte proliferation in response to a mitogen was significantly lower in severely or moderately depressed patients when compared to control (P<0.05). These data confirm the immunological disturbance of acute phase proteins and cellular immune response in patients with depression. Other results may be explained by a variety of interacting factors such as number of patients, age, sex, and the nature, severity and/or duration of depression. Thus, the data obtained should be interpreted with caution and the precise clinical relevance of these findings requires further investigation
Asunto(s)
Humanos , Masculino , Femenino , Adolescente , Adulto , Persona de Mediana Edad , Proteínas Sanguíneas , Citocinas , Depresión , Hormonas , División Celular , Citocinas , Hormonas , Linfocitos , Pacientes Ambulatorios , Receptores de Interleucina-2 , Albúmina Sérica , Seroglobulinas , Índice de Severidad de la EnfermedadRESUMEN
Com o objetivo de determinar o estado nutricional das crianças de 0 a 6 anos do Jardim Uniäo da Vitória, Zona Sul de Londrina, analisou-se uma amostra de 241 crianças entre 0 a 6 anos de idade atendidas na Unidade Básica de Saúde Orlando Cestari, localizada no Jardim Uniäo da Vitória. Os dados antropométricos (peso e altura) e outros obtidos através de um questionário contendo informaçöes sobre o nível de escolaridade, renda familiar, realizaçäo de pré-natal pelas mäes, uso de drogas e tabaco na gravidez, baixo peso ao nascer, ocorrência de hospitalizaçäo por infecçäo nos últimos 12 meses, foram analisados estatisticamente pelo Teste do Qui- quadrado ou Teste Exato de Fisher. Os resultos obtidos demonstraram que 33 por cento das crianças apresentam desnutriçäo. Os fatores associados na determinaçäo da desnutriçäo da populaçäo estudada foram o baixo peso ao nascer em menores de 12 meses e maior número de hospitalizaçöes por infecçäo