RESUMEN
Serial colposkopic and cytologic observations of a 38-year-old patient in her first pregnancy show the development of a dysplasia from papilloma of the cervix within 6 months. Papilloma virus must be regarded as an infectious oncogenous agent in the region of the human cervix.
Asunto(s)
Papiloma/diagnóstico , Complicaciones del Embarazo/diagnóstico , Displasia del Cuello del Útero/diagnóstico , Neoplasias del Cuello Uterino/diagnóstico , Adulto , Carcinoma in Situ/diagnóstico , Carcinoma in Situ/cirugía , Colposcopía , Citodiagnóstico , Femenino , Humanos , Embarazo , Complicaciones del Embarazo/cirugía , Factores de Tiempo , Neoplasias del Cuello Uterino/cirugíaRESUMEN
Human genital tumors as well as recurrent laryngeal papillomas were analyzed for the presence of human papillomavirus (HPV) 6 and HPV 11 sequences. HPV 11 DNA was found in 7 of 14 laryngeal papillomas; in the 7 other tumors no HPV DNA was demonstrated. HPV 11 DNA was also found in all five atypical condylomata of the cervix included in this study. Condylomata acuminata mainly contained HPV 6 DNA. From 63 biopsy specimens, 41 clearly harbored HPV 6 DNA and 13 harbored HPV 11 DNA. In three tumors accurate typing was impossible, and in six additional ones neither HPV 6 nor HPV 11 DNA could be demonstrated. The data support a genital origin of laryngeal papillomavirus infections. In 4 of 24 malignant tumors, HPV 11 DNA or related sequences were demonstrated; 2 of the 4 were biopsy specimens from invasive cancer, and the other 2 originated from carcinomata in situ. A possible role of this or related papillomavirus types in the induction of malignant genital tumors remains to be elucidated.
Asunto(s)
ADN Viral/aislamiento & purificación , Neoplasias de los Genitales Femeninos/microbiología , Neoplasias Laríngeas/microbiología , Papiloma/microbiología , Papillomaviridae/genética , Neoplasias del Cuello Uterino/microbiología , Carcinoma de Células Escamosas/microbiología , ADN Viral/genética , Femenino , Humanos , Peso Molecular , Hibridación de Ácido NucleicoRESUMEN
Cell-free extracts were prepared from tissue specimens of intraepithelial carcinoma of the cervix uteri of human patients and subsequently injected into newborn and juvenile mice of NMRI strain via several routes. Cytological controls of vaginal epithelium were carried out in periods of 8--12 wk. Groups of mice were killed at varying intervals for histological examination. After a latency of 4-8 mth dysplastic changes of the vaginal epithelium were found in 67.6% (48 out of 71) of the mice and were graded as hyperplasia, mild and severe dysplasia and carcinoma in situ. Antibody against herpes virus hominis was not detected in the sera of these mice. Only 1 out of 120 control mice had mild dysplasia 16 mth after inoculation of an extract from noninfected human embryo kidney cells. In 9 out of 10 human cases of histologically confirmed cervical carcinoma in situ, injection of extracts into mice was followed by the appearance of dysplastic epithelium in the murine vagina. In the one case in which no positive response was obtained, the observation time had been less than 6 mth.
Asunto(s)
Carcinoma in Situ/patología , Displasia del Cuello del Útero/patología , Neoplasias del Cuello Uterino/patología , Vagina/patología , Animales , Epitelio/patología , Femenino , Humanos , Ratones , Trasplante de Neoplasias , Trasplante HeterólogoRESUMEN
At the Gynecological University Hospital in Marburg/Lahn, 190 women with cancer of the ovary who had been under clinical treatment from 1962--July 1976 were studied epidemiologically. Special risk factors which seem to predispose to the development of cancer of the ovary were determined. Higher social standing, having no children or having born more than four children, a shortened menarche-menopause interval, having had radiation of the pelvis, as well as having had an appendectomy seem to be factors overrepresented among cancer patients in Marburg. More patients had blood group A and fewer had blood group O than would be expected from the distribution in the population as a whole. Polyps of the corpus uteri were often seen to precede cancer of the ovary. Diabetes mellitus, adiposity, hypertension and varicosis were frequent accompanying diseases. Many patients had a fmily history of cancer.