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Enzymatic activities of cytoplasmic and of microsomal acetyl-CoA carboxylase of rat epididymal adipose tissue; different regulatory effects of a short-term fasting and palmitoyl-CoA on these two enzymes.

Imesch, E; Wolczunowicz, M; Rous, S.

Int J Biochem ; 15(7): 977-80, 1983.

Artículo en Inglés | MEDLINE | ID: mdl-6136428

RESUMEN

The existence of a microsomal acetyl-CoA carboxylase in the rat epididymal adipose tissue was demonstrated in vitro in the present study. Its specific activity was of the same order of magnitude as that of the cytoplasmic acetyl-CoA carboxylase. The effect of several experimental conditions on the enzymatic activities of both enzymes were tested; fasting for 24 hr strongly increased (2.5-4 times) the activity of the microsomal enzyme while the cytoplasmic enzyme remained unchanged. Palmitoyl-CoA (1 and 5 microM), an inhibitor of acetyl-CoA carboxylase, had a greater effect on the cytoplasmic (33 and 88% inhibition) than on the microsomal enzyme (0 and 37% inhibition).

Asunto(s)

Acetil-CoA Carboxilasa/metabolismo , Acilcoenzima A/farmacología , Tejido Adiposo/enzimología , Citoplasma/enzimología , Ayuno , Ligasas/metabolismo , Microsomas/enzimología , Palmitoil Coenzima A/farmacología , Animales , Epidídimo/enzimología , Masculino , Ratas , Ratas Endogámicas , Factores de Tiempo

Regulation of cytoplasmic acetyl-CoA and acetoacetyl-CoA synthetases by dexamethasone phosphate in rat liver and adipose tissue.

Wolczunowicz, M; Rous, S.

Life Sci ; 20(8): 1347-52, 1977 Apr 15.

Artículo en Inglés | MEDLINE | ID: mdl-16190

Asunto(s)

Acetato CoA Ligasa/metabolismo , Tejido Adiposo/enzimología , Coenzima A Ligasas/metabolismo , Dexametasona/farmacología , Hígado/enzimología , Acetoacetatos , Tejido Adiposo/efectos de los fármacos , Animales , Ayuno , Hígado/efectos de los fármacos , Masculino , Ratas

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