RESUMEN
The authors have made a detailed study of 202 cases recognized as early RA. All of them were referred to the Institute for thorough examination and were afterwards followed up for two to six years. The observation of the course of the disease revealed four groups: 1. Cases where development of bone erosions proved the diagnosis of RA, 2. Cases in whom all previous symptoms and signs disappeared, 3. Cases in whom diagnosis could not be established after follow-up, 4. Cases in whom other diseases were manifest. The first two groups were analysed retrospectively to find the characteristic features in the early stages of RA.
RESUMEN
A case of desmoplastic cerebellar medulloblastoma with numerous metastases beyond the nervous system is reported. Fourteen months after the operation the patient began complaining about pains in hip and knee joints and dysphagia. One week before death profuse bleeding from the digestive tract developed. On autopsy numerous metastases were found in the bones, lymph nodes, spleen, pancreas and kidneys. Histological examination demonstrated that the metastases were composed of the same cells as the primary cerebellar tumour, but reticulin fibres were scant in them. In none of the metastatic lesions any significant reticulin proliferation was present, these fibres were found only around small vessels.