RESUMEN

Increased numbers of apoptotic neutrophils are found in SLE, related to disease activity and levels of anti-dsDNA antibody. The mechanism of increased apoptosis is not clear, but anti-dsDNA antibody has been shown to induce apoptosis in neutrophils from normal subjects and in certain cell lines. In this study, polyclonal anti-dsDNA antibody was isolated from the serum of a patient with active SLE, and was shown to substantially accelerate apoptosis in neutrophils from SLE patients as compared with neutrophils from healthy control or rheumatoid arthritis subjects.

Asunto(s)

Anticuerpos Antinucleares/inmunología , Apoptosis/inmunología , Lupus Eritematoso Sistémico , Neutrófilos/inmunología , Anticuerpos Antinucleares/efectos adversos , Células Cultivadas , ADN/inmunología , Humanos , Lupus Eritematoso Sistémico/sangre , Lupus Eritematoso Sistémico/inmunología , Proyectos Piloto