RESUMEN
Four patients with chronic inflammatory demyelinating polyneuropathy (CIDP) who were refractory to conventional treatment were treated with high-dose cyclophosphamide (200 mg/kg over 4 days). All improved in functional status and muscle strength. Nerve conduction studies improved in three of four. Other immunomodulatory medications have been discontinued. High-dose cyclophosphamide can be given safely to patients with CIDP and patients with disease persistence after standard therapy may have a response that lasts for over 3 years and results in long-term disease remission.
Asunto(s)
Ciclofosfamida/administración & dosificación , Inmunosupresores/administración & dosificación , Polirradiculoneuropatía Crónica Inflamatoria Desmielinizante/tratamiento farmacológico , Trasplante de Células Madre , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Polirradiculoneuropatía Crónica Inflamatoria Desmielinizante/inmunología , Polirradiculoneuropatía Crónica Inflamatoria Desmielinizante/fisiopatología , Células Madre/inmunología , Resultado del TratamientoRESUMEN
Isolated inferior division third nerve palsies are rare. The authors report a patient with an isolated, pupil-involving inferior division third cranial nerve palsy from an intraorbital dural arteriovenous malformation. Despite spontaneous thrombosis of the malformation, the third nerve palsy persisted. To the authors' knowledge, this is the first case report of an inferior division third nerve palsy caused by an orbital dural arteriovenous malformation.
Asunto(s)
Malformaciones Arteriovenosas/complicaciones , Duramadre/irrigación sanguínea , Enfermedades del Nervio Oculomotor/etiología , Arteria Oftálmica/anomalías , Órbita/irrigación sanguínea , Adulto , Angiografía , Malformaciones Arteriovenosas/diagnóstico , Exoftalmia/diagnóstico , Exoftalmia/etiología , Femenino , Humanos , Imagen por Resonancia Magnética , Arteria Oftálmica/diagnóstico por imagen , Venas/anomalíasAsunto(s)
Hemangioma/complicaciones , Complicaciones Neoplásicas del Embarazo/diagnóstico , Compresión de la Médula Espinal/etiología , Neoplasias de la Columna Vertebral/complicaciones , Vértebras Torácicas/patología , Adulto , Femenino , Hemangioma/diagnóstico , Humanos , Imagen por Resonancia Magnética , Embarazo , Neoplasias de la Columna Vertebral/diagnósticoRESUMEN
A case of progressive multifocal leukoencephalopathy (PML) with selective involvement of cerebellum and brain stem is compared with nine other published cases. Recognition of PML presenting with ataxia before cerebral manifestations is stressed especially, since promising results with some antiviral drugs have been claimed.