RESUMEN

A retrospective review of 95 consecutive primary total hip arthroplasty patients was performed to assess the clinical outcome of two postoperative bladder management protocols. The first 49 patients (group 1) were treated with a pro re nata straight catheterization protocol. The next 46 patients (group 2) were treated with an indwelling catheterization protocol. There were no differences between the groups with respect to sex or age. The patients in group 2 had significantly lower incidences of urinary retention (P < .0005) and bladder distention (P < .0005) than those in group 1. Preoperative systemic diseases and urologic symptoms did not correlate with the occurrence of postoperative urinary retention or bladder distention. There were no infections in group 1. In group 2, one patient (2%) had bacteriuria and one patient (2%) had a urinary tract infection (P > .1). This trend of increased contamination in the catheterization group may be related to a mean catheterization duration of 72 hours.

Asunto(s)

RESUMEN

1. Rats in respiration chambers were grown for 32 days and their weight reduced by 27-40% on three occasions and realimentated. After the first cycle rats lost body weight more rapidly and regained that weight more quickly than previously. 2. The initial growth phase took 32 days compared with only 8 days in the final period. Each gram of weight gain was associated with 13-14 kJ of dietary net energy during the last two periods of realimentation compared with 19-20 kJ during the first period. 3. Calorimetric measurements showed that although maintenance energy requirement increased during the periods of growth, mean net availability of metabolizable energy was 0.91 compared to 0.60 during weight loss. 4. During the final period much of the weight gain was in the form of lean (67%) but the majority of energy retained was as fat (67-70%).

Asunto(s)

RESUMEN

1. Six young adult female rats were subjected to 40% body weight loss in 84 days by food restriction followed by recovery of body weight in 36.2 +/- 4.28 days by ad libitum food intake. The regimen was then repeated, with 40% body weight loss in 105 days followed by recovery of body weight in 22.8 +/- 2.00 days. 2. Food intakes were measured continuously. 3. These rats used digestible energy more efficiently during the second recovery (49.1 +/- 3.11 v. 77.3 +/- 7.91 kJ digestible energy intake per g body wt gain). 4. Seven rats were subjected to one body weight loss and recovery. Five of them had an efficiency of 44.1 +/- 3.34 kJ/g live wt gain which was not significantly different from that of the first group during their second recovery; they may not have been capable of improvement after a second deprivation. 5. It is concluded that some rats can adapt after a period of severe body weight loss and recovery to utilize food more efficiently during body weight recovery after a second episode.

Asunto(s)

RESUMEN

1. Sheep were given 800 g low-protein roughage/d at 2 h intervals and infused intraruminally with 0,500, 750, 1000, 1250, 1500 or 2000 mmol sodium chloride/d in 436 ml water. The digestibility of various food fractions and rumen ammonia, volatile fatty acids (VFA) and liquid turnover rate were measured, along with renal haemodynamics and the renal excretory patterns of nitrogen and electrolytes. Ad lib. food intake was determined during the infusion of 0 and 2000 mmol NaCl/d. 2. Infusion of NaCl up to 750 mmol/d had virtually no effect on the indices measured, except water intake and water excretion. Infusion of greater amounts caused a step-wise decrease in the digestibility of organic matter (OM) and N. Rumen liquid turnover rate was increased substantially and rumen NH3 and VFA concentrations were decreased. Ad lib. food intake was not different when either 0 or 2000 mmol NaCl/d were infused into the rumen. 3. The glomerular filtration rate and effective renal plasma flow (ERPF) were substantially increased after the infusion of 1250 mmol or more NaCl/d. Extracellular fluid volume was also increased. The renal excretion of urea and uric acid + allantoin (URAL) were decreased at the higher infusion rates but the fractional excretions of both these substances were enhanced. The excretion of sodium, chloride, calcium and magnesium were markedly increased with increasing salt infusion. 4. The results suggest that high NaCl inputs into the rumen increase the rumen turnover rate, which in turn decreases the digestibility of OM, particularly N. This causes lower rumen NH3 and VFA concentrations. Plasma urea and URAL concentrations are also decreased and this causes lower renal excretion of these substances despite a much higher fractional excretion resulting from the greatly enhanced urine flow rate. 5. When roughages low in N are given, NaCl intake should be kept below 20 mmol/kg body-weight per d to prevent a decline in the digestibility of the food and any consequent reduction in protein available to the sheep.

Asunto(s)

RESUMEN

The rate of passage of digesta and the digestibility of a nonpurified diet were studied in adult female rats prevented from coprophagy on alternate weeks by confinement to their normal feeding tunnels in metabolism cages. In food-restricted rats a decrease in the time for the first appearance in the feces of a digesta marker was noted when prevention of coprophagy was followed by permitting rats to feed on their feces while being maintained on a restricted food intake, as compared to control rats permitted coprophagy throughout. The prevention of coprophagy had no effect on the rate of passage of digesta along the small intestine. The prevention of coprophagy had no effect on the apparent digestibility of dry matter, organic matter, energy or protein when the rats were fed ad libitum. However, when rats had lost 20% or more of their body weight by restricted feeding, digestibility of the measured constituents of the food offered in restricted amounts increased, but this effect was abolished when coprophagy was prevented.

Asunto(s)

RESUMEN

Two merino ewes were fed 800 and then 1000 g of lucerne chaff per day and renal responses and extracellular fluid volume (E.C.F.) were determined. Urine urea nitrogen, glomerular filtration rate (G.F.R.), urine volume, effective renal plasma flow (E.R.P.F.) and E.C.F. increased in both animals with the greater nitrogen intake. In a second experiment, five merino wethers and four merino ewes were infused intraruminally with increasing quantities of urea, whilst being fed a mainly roughage ration, and the above parameters were determined. No significant changes in G.F.R., E.R.P.F. or E.C.F. were noted. Urinary excretion maintained a linear response to nitrogen input until 20.6 g of urea nitrogen per day were infused. At this level of infusion, an increased fractional reabsorption of urea resulted in a large increase in plasma urea concentration, but when 500 mmol of NaCl or KCl were added to the infusate, urine urea nitrogen excretion increased from 10.4 to 11.4 and 11.9 g/d respectively and plasma urea concentration decreased from 68.0 to 35.2 and 37.3 mg nitrogen/100 ml. Urea clearance virtually trebled with both electrolyte infusions and E.C.F. and G.F.R. increased by approximately 10 and 25% respectively. It is concluded that urea alone has limited diuretic ability and that the increased electrolyte content of higher protein dry roughage diets aids urine urea excretion by increasing G.F.R., and the urine flow rate by an osmotic diuretic effect.

Asunto(s)

RESUMEN

Minimum transit time through the alimentary tract of young adult female rats fed a stock diet ad libitum was reduced from 6.6 +/- 0.4 h for sham-operated rats to 5.0 +/- 0.3 h for caecectomized rats, but there was no effect on transit time of digesta along the small intestine. Caecectomy decreased the apparent digestibility of crude protein, soluble carbohydrate, cellulose and hemicellulose. Digestibility of lipid was not affected. However, caecectomized rats did not increase their dry matter intakes to compensate for the reduced digestible energy intakes.

Asunto(s)

RESUMEN

Metabolic fecal nitrogen was measured in young adult female rats fed synthetic diets before and after weight losses had been caused by restricted food intake. When food intake was decreased from 5.5 to 2.4 g or from 6.7 to 2.3 g per 100 g body weight per day, metabolic fecal nitrogen per gram food intake increased by 48 and 59%, respectively. However, weight losses did not affect metabolic fecal nitrogen excretion significantly until some 40% loss of weight had been obtained. At this point metabolic fetal nitrogen excretion was observed to increase by 11%. These results indicate that the 6% increase in apparent digestibility of crude protein in a stock diet which occurs during food restriction is due to a genuine increase in absorption of dietary nitrogen.

Asunto(s)

RESUMEN

Caecectomized and sham-operated rats were fed a laboratory chow ad libitum and the effects of caecectomy on the digestibility of the food were studied. Compared with sham-operated controls, caecectomized rats showed a decrease in apparent digestibiltiy of organic matter from 77.8 to 73.0%, of crude protein from 83.0 to 79.4%, and of 'carbohydrate' from 74.6 to 69.0%. However, faecal water content increased from 41.6 to 54.8%. 51Cr-labelled EDTA was excreted faster in the faeces after caecectomy. The colon partly adapted to the loss of caecal mucosa by increased length and thus mucosal surface area. In a second concurrent experiment the effect of caecectomy on the apparent digestibility of food during food restriction was studied. Six caecectomized rats, comparable in all respects to those used in the first study, were fed the laboratory chow ad libitum for 3 weeks. They were then fed submaintenance amounts of food to achieve body weight losses of 40--50% and to maintain these low weights for 4 weeks. Finally, they were again fed ad libitum for 3 weeks. During the period of restriction the apparent digestibility of organic matter increased from 72.7 to 75.4%. This was largely due to the increased apparent digestibility of crude protein which rose from 78.4 to 81.9%. Digestibility coefficients returned to control values immediately upon refeeding ad libitum.

Asunto(s)

RESUMEN

Changes in body composition were studied in three groups of young adult female rats; the treatments were (1) ad libitum food intake to obtain normal growth, (2) restricted food intake to cause body weight loss, and (3) restricted followed by ad libitum food intake to obtain recovery of lost body weight. In each of the three groups of rats the percentage body water was linearly and negatively correlated with the percentage body fat, the weight of body water was linearly and positively correlated with the weight of body protein, and the ratio of the weight of body protein to water was relatively constant at 1:3.20 +/- 0.02 (mean +/- standard error). The percentage body water in the fat-free body was linearly and negatively correlated with fat-free body weight during normal growth between 109 and 334 g body weight but positively correlated during body weight loss and recovery. During recovery of body weight rats laid down more fat and less protein than during normal growth through the same body weight range and the percentage of digestible energy retained as body tissue was increased.

Asunto(s)

RESUMEN

The apparent digestibilities of organic matter, protein, lipid and carbohydrate of a laboratory chow were determined in young adult female rats fed ad libitum, after losing 40-50% body weight and prolonging the loss for up to 15 weeks, and while recovering the lost body weight during a second period of ad libitum food intake. During deprivation the animals increased the apparent digestibility of crude protein but there was no significant change in digestibility coefficients of lipid or carbohydrate in relation to treatments. When food was again offered ad libitum to the deprived animals they ate large amounts compared with their body weights but normal amounts when compared with their age peers. Apparent crude protein digestibility immediately returned to pre-deprivation values. No impairment of ability to ingest and digest quantities of food relative to age was detected.

Asunto(s)

Asunto(s)

RESUMEN

Changes in jugular haematocrit during daily 2-h feeding periods in trained sheep with and without spleens were compared with changes in the concentration of the plasma tracer radio-iodinated human serum albumin. Jugular haematocrit was increased by 16% in intact sheep and 9% in splenectomized sheep 20 min after they started to eat dry rations. The dilution of tracer in plasma, studied after mixing in the vascular system had been completed, showed four phases. Phase 1 was the rate of removal of tracer in the period before eating began. Phase 2 was the sudden increase in plasma radioactivity that occurred in the first 20 min of eating, indicating a loss of plasma from the circulation. Phase 3 was the decrease in tracer concentration during the remaining feeding period and phase 4 was a post-feeding phase, characterized by a slower rate of decrease of tracer than during phase 3, implying that there was significant recycling of tracer during this phase. The sudden increase in plasma radioactivity, initiated by the onset of feeding, represented a reduction in plasma volume of 10-12%. Minimum plasma volume coincided with peak haematocrit values. The reduced plasma volume accounted for the increased haematocrit in splenectomized sheep, but only accounted for about half of the increase in intact sheep. The residual increase in haematocrit in intact sheep was most likely the result of splenic contraction.

Asunto(s)

RESUMEN

1. The effect of different protein sources in milk-substitute diets on abomasal acidity and proteolytic activity was studied in Friesian calves, aged 20-58 d (Expt 1). The diets contained 'mildly' preheated, spray-dried skim-milk powder (MHM), severely preheated, spray-dried skim-milk powder (SHM), fish-protein concentrate (FPC) or solvent-extracted soya-bean flour (SF) as the main protein source. 2. Gastric juice was collected from abomasal pouches before feeding and at 15 min intervals for 8 h after the morning feed. Samples of digesta were obtained from the abomasum at 1 h intervals during the same period. 3. Digesta pH was lower and titratable acidity higher 0-3 after giving the diet containing MHM than when any of the other three diets was given. 3. Acid secretion from the pouches for the different diets was in the order: FPC greater than MHM greater than SHM greater than or equal to SF. 5. Protease secretion from the pouches, assayed at pH 2-1, was in the order: MHM greater than SHM = FPC greater than SF. 6. The effect of dry matter (DM) intake and concentration on abomasal acidity was also studied in calves given diets which contained MHM (Expt 2). This diet was reconstituted at either 100 or 149 g DM/kg liquid diet and fed at either 32-5 or 49-0 g DM/kg live weight 0-75 per d. Samples of abomasal digesta were collected as in Expt 1. 7. A high intake of DM at a low DM concentration resulted in low acidity of the digesta in the first 3 h after feeding, which suggested a dilution effect. Comparison of two diets of different DM concentration, which were fed in the same volume of liquid, indicated that the greater the DM intake, the greater was the amount of acid secreted. 8. It is concluded that the protein sources varied in their ability to stimulate abomasal acid and protease secretion and it is suggested that this may relate to calf performance.

Asunto(s)

RESUMEN

Sixteen female rats aged about 80 days and with a mean body weight of 175 g were fed 40% of their ad libitum intake of a laboratory chow. They were killed and analysed for water, protein, lipid and ash after 9, 21-5, 30-2 and 38-8% of body weight had been lost. Compared to a control group of four animals, the 38-8% group lost 13 g or 34% of their protein. The animals in the 21-5, 30-2 and 38-8% groups lost 7-5 g or 87% of their lipid leaving only 1-1 g of lipid. The percentage protein in the body was little affected by body weight loss but lipid decreased from 5 to 1%. In another experiment with 26 rats of 205 g mean body weight and aged about 115 days, absorption rates by the small intestine were measured in vivo after variable weight losses between 0 and 39%. D(+)-Glucose uptake was increased by about 70% in those animals which had lost only 5% of body weight and this increased uptake was retained in those rats which had lost up to 39% of body weight. The absorption of L-leucine was not affected by the decline in body weight compared to the controls but relative to body weight, the ability of the intestine to absorb increased. In the same animals, the wet and dry weights of the small intestine declined slightly faster than body weight and the length of the small intestine tended to decrease slightly with increasing loss of body weight.

Asunto(s)

RESUMEN

Insulin hypoglycaemia, by acting as a stressor, caused an increase in plasma corticosteroid concentration in sheep. It did not increase jugular haematocrit in splenectomized sheep, but caused an increase, presumably by splenic contraction, in the following sheep: two control, one with one adrenal cortex as its only adrenal tissue, two with denervated spleens, and two splanchnicotomized animals. These preparations showed that insulin hypoglycaemia can cause a splenic contraction in the absence of an increase in plasma adrenaline and after splenic extrinsic denervation.

Asunto(s)

RESUMEN

Intact and splenectomized sheep with and without a rumen fistula were used to investigate changes in the jugular blood haematocrit and plasma osmolality during hourly and once-daily feeding regimes. Osmolality was also estimated in the ruminal fluid of fistulated sheep with spleens. Haematocrit decreased in sheep with spleens before they were given a once-daily feed; it increased when these sheep started to feed, reaching a maximum increase of 13% after 30 min of feeding; it decreased during the remaining 45 min of feeding time and usually continued to decrease after feeding stopped. These changes were not due to diurnal influences. Splenectomized sheep fed once daily showed only small decreases in haematocrit before they were fed. Increases occurred with the onset of eating but they were smaller (7%) than in intact sheep and were of shorter duration. In hourly fed sheep with spleens, haematocrit decreased in the early stages of sampling in a manner similar to that for sheep fed once daily. The changes in haematocrit that did occur were not related in any obvious manner to the feeding regime. The haematocrit in splenectomized sheep fed hourly was stable throughout feeding. Variations in the haematocrit in splenectomized sheep, equivalent to a range of 13% in one of them, were observed in a series of blood samples obtained during a 5-h period remote from the feeding time. Large increases occurred in osmolality of ruminal fluid when sheep were fed daily and this was abolished by hourly feeding. Plasma osmolality in sheep fed once daily increased slowly. Maxima occurred after 100 min from the start of eating and were 7% greater than prefeeding values. Only minor changes were observed when these sheep were fed hourly.

Asunto(s)

RESUMEN

1. Food consumption, live weight, anatomical measurements on the gut organs and the absorptive capacity of the small intestine for L-leucine and D(plus)-glucose were made on virgin (control), pregnant and lactating albino rats. 2. Food intake increased by approximately 60% during pregnancy and a further 250% during lactation. 3. Pregnancy did not markedly influence the gross anatomy of the gastrointestinal tract. There was evidence for increased villus height and percentage water in the small intestine and for increased length of the colon during pregnancy. 4. During lactation, the alimentary canal progressively increased in weight and size. It partially regressed following weaning. 5. All anatomical measurements, except the length of the small intestine, completely regressed to control values within 20 d of weaning. The increased intestinal length had not completely regressed by day 30 post-weaning. 6. No significant change was observed in absolute absorption of glucose or leucine during pregnancy. 7. Absolute absorption of leucine and of glucose was increased during lactation. Greatest absorption occurred on the 10th day of lactation. 8. Results for absorption of leucine and glucose per unit length indicated that the ability of the mucosal cells to absorb or the number of absorptive cells/mm had changed during lactation and the post-lactation periods.

Asunto(s)

Asunto(s)

Asunto(s)