RESUMEN

We studied Ca and Mg and trace elements (Zn, Cu, Fe, Mn, Se) in 15 P.K.U. children treated with strict Phe-reduced diet and in a control group. P.K.U. children are significantly lower (p < 0.01) plasma and erythrocyte Se as well as significantly lower (p < 0.01) activities of Glutathione-Peroxidase (GSH-Px), a seleno-dependent enzyme in erythrocytes and in plasma. Concomitantly with defective GSH-Px activities we observe significantly (p < 0.01) increased levels of lipid peroxidation products: malonaldialdehyde (MDA) and organic hydroperoxides (O.H.P.). So, Se supplementation appears to be necessary in low phenylalanine products used in P.K.U. treatment.

Asunto(s)

Humanos , Masculino , Femenino , Lactante , Preescolar , Niño , Peroxidación de Lípido/fisiología , Fenilcetonurias , Selenio , Oligoelementos , Glutatión Peroxidasa , Malondialdehído/sangre , Fenilalanina , Fenilcetonurias , Selenio