RESUMEN
PURPOSE: The aim of this study was to evaluate the influence of LY300164 (an AMPA/kainate receptor antagonist) administered alone or in combination with valproate (VPA) or phenobarbital (PB) on body temperature in mice. MATERIAL AND METHODS: The temperature measurements were performed in Albino Swiss mice injected with the respective drugs by using a rectal thermistor thermometer. RESULTS: LY300164, at the dose of 2 mg/kg, did not affect the body temperature of the examined animals. However, the combination of LY300164 (2 mg/kg) with VPA (165 mg/kg) resulted in a significant decrease in body temperature within 60-180 min after their peak of maximum anticonvulsant activity. Moreover, VPA (269 mg/kg) administered alone, evidently produced hypothermic effects at the times between 120-180 min after the peak of the maximum antiseizure effect. In contrast, phenobarbital administered alone or in combination with LY300164 did not affect the body temperature in the mice. CONCLUSIONS: Hypothermia induced by LY 300164 combined with VPA may be useful in various central nervous system disease treatments.