RESUMEN
OBJECTIVES: Despite the excellent overall survival of 92%-97% in early glottic cancer, recurrence rates of 13%-20% have not improved in the last decades. The engulfment and cell motility protein 3 (ELMO3) have been described as prognostic marker in patients with lung cancer. The aim of this study was to investigate the expression of ELMO3 in early laryngeal cancer patients treated with TLM and to evaluate its prognostic significance on clinical outcome. DESIGN, SETTING AND PARTICIPANT: Forty-eight patients with glottic carcinoma (T1N0M0) that underwent primary treatment with TLM between 1994 and 2012 were analysed. ELMO3 expression of the tumour was assessed using immunohistochemistry and correlated with clinical data. MAIN OUTCOME MEASURE: Overall survival, disease-specific survival (DSS) and disease-free survival (DFS) rates RESULTS: Positive ELMO3 expression was found in 23% of the patients and was correlated with poor DSS and DFS (P<.05). CONCLUSION: This is the first study to show a prognostic effect of positive ELMO3 expression in early glottic carcinoma patients.
Asunto(s)
Proteínas Adaptadoras Transductoras de Señales/metabolismo , Carcinoma de Células Escamosas/metabolismo , Proteínas del Citoesqueleto/metabolismo , Glotis , Neoplasias Laríngeas/metabolismo , Terapia por Láser , Microcirugia , Adulto , Anciano , Carcinoma de Células Escamosas/mortalidad , Carcinoma de Células Escamosas/cirugía , Supervivencia sin Enfermedad , Femenino , Humanos , Neoplasias Laríngeas/mortalidad , Neoplasias Laríngeas/cirugía , Masculino , Persona de Mediana Edad , Estadificación de Neoplasias , Valor Predictivo de las Pruebas , Estudios Retrospectivos , Tasa de Supervivencia , Resultado del TratamientoRESUMEN
The aim of this work was to examine the influence of the filter kernel size on the detectability of differing radiological findings in interstitial lung disease. In 97 patients with confirmed pulmonary fibrosis chest radiographs were obtained with a filmscreen system of speed class 200 and with correspondingly exposed storage phosphorous plates. The size of the filter kernel used for the image postprocessing varied between sigma 5 and sigma 70. The detectability of interstitial lung changes was evaluated independently by eight readers on the basis of a defined rating system. The results were analysed using multifactorial analysis of variance with Scheffé test at a significance level of p = 0.05. Small kernel sizes (S 5, S 10) combined with high edge enhancement were only of benefit in the imaging of septal lines, but reduced the detectability of nodular and reticular structures. Good detail detectability of both micronodules and septal lines was obtained with a medium kernel size of sigma 40. Storage phosphor radiography utilizing the appropriate choice of postprocessing parameters provides equivalent image quality for evaluating interstitial lung changes compared with a modern filmscreen technique.
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Fibrosis Pulmonar/diagnóstico por imagen , Intensificación de Imagen Radiográfica , Pantallas Intensificadoras de Rayos X , Femenino , Humanos , Pulmón/diagnóstico por imagen , MasculinoRESUMEN
PURPOSE: To compare the performances of 4 imaging systems in the diagnostic radiology of the chest: an asymmetric screen-film combination (a-SFC); a conventional screen-film combination of speed class 200 (SFC); a screen-film combination of speed class 200 with an aluminium lung filter; and digital luminescence radiographs (DLR). MATERIAL AND METHODS: Object detectability studies were carried out using an anthropomorphic chest phantom. The images were obtained under standard exposure conditions at 125 kVp. The detection performance of the various systems was evaluated by receiver operating characteristic (ROC) analysis on the basis of a total of 12,240 observations. RESULTS: In the overall evaluation the a-SFC and the SFC plus lung filter received equally high ratings of 0.878+/-0.018 and 0.860+/-0.21, respectively (p>0.05). There was no significant difference between the 200-speed SFC and the storage phosphor radiographs. In the mediastinum all the tested systems were clearly superior to the 200-speed SFC (p<0.05) while in the lung fields the 200-speed SFC received a high rating of 0.866+/-0.026. The a-SFC had slight advantages over the SFC plus lung filter and the 2 digital imaging modes (p>0.05). CONCLUSION: The a-SFC and the digital luminescence radiographs provide a significant gain in diagnostic information in the mediastinum without diminishing detail detectability in the lung fields and without additional radiation exposure.
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Intensificación de Imagen Radiográfica , Radiografía Torácica/métodos , Pantallas Intensificadoras de Rayos X , Filtración , Humanos , Enfermedades Pulmonares/diagnóstico por imagen , Fantasmas de Imagen , Curva ROC , Radiografía Torácica/instrumentación , Sensibilidad y EspecificidadRESUMEN
PURPOSE: The aim of the study was to optimize the postprocessing of digital luminescence radiographs of interstitial infiltrates of the lung. MATERIAL AND METHODS: Ninety-seven patients with established diseases of the lung parenchyma were examined: 514 pathological details were investigated, using a 200-speed screen-film system and a storage phosphor plate. In digital postprocessing, the size of the filter kernel (S) varied between S 5 and S 70. Based upon 32896 individual evaluations, the image quality was evaluated in multifactorial variance analyses. RESULTS: The digital standards were significantly inferior to the tested screen-film system. The large filter kernel S 70 and the small filter kernels S 5 and S 10, as well as an algorithm for edge enhancement, showed selective advantages in the depiction of nodular or small linear structures. For micronodular and linear structures, kernel sizes of S 20 and S 40 produced equally good results (p > 0.05). CONCLUSION: Whenever optimized postprocessing is involved, storage phosphor radiography is equal to a modern screen-film system and can be substituted for the latter without any loss of image quality; this is especially valid for the imaging of interstitial infiltrates of the lung.
Asunto(s)
Enfermedades Pulmonares Intersticiales/diagnóstico por imagen , Intensificación de Imagen Radiográfica/métodos , Femenino , Filtración/instrumentación , Humanos , Masculino , Intensificación de Imagen Radiográfica/instrumentación , Pantallas Intensificadoras de Rayos XRESUMEN
AIM: To compare in mammography the image quality of digital luminescence radiography (DLR) to that of usual film screen mammography and xeromammography. MATERIALS AND METHODS: Three single emulsion film-screen combinations, one double coated high resolution film and xeroradiography, were tested for this purpose. In our phantom study the detectability of microcalcifications, fibrils and low contrast details were first of all studied separately. Image processing techniques were, for example, contrast variation by grey scale level windowing, "unsharp mask" filtering and regulatable edge enhancement. Phantom images were made and then the image quality was evaluated by observer performance study using a receiver operating characteristic (ROC analysis). RESULTS: Best results in respect of detection of microcalcifications and fibrils were found in xeroradiography, luminescent image plate and double-coated film-screen combination. These systems showed more favourable ROC curves than the single emulsion film-screen combinations. CONCLUSIONS: Our results indicate that image quality of digital images in the field of image processing is equal to that of conventional mammographic techniques and partially superior to detection of low contrast details.