RESUMEN
The Human Genome Project is an international effort to map and sequence the human genome. The information it will generate has been referred to by some as the "new anatomy," and may play an important role in the future of medicine. However, as with any new technological advancement, the outcome of the Human Genome Project and the subsequent availability of new technology will raise a myriad of ethical, legal, and social concerns. The fear is that this technology will be applied in the clinical setting before the appropriate infrastructure is in place to deal with the issues it will raise. The family physician, far from being merely an interested observer in this process, will be responsible for the delivery of much of this technology as it becomes available. As an intermediary between the technology and the individual patient, the physician has a unique obligation to join in the thoughtful consideration and debate of these issues.
Asunto(s)
Medicina Familiar y Comunitaria , Proyecto Genoma Humano , Aborto Inducido , Confidencialidad , Ética Médica , Medicina Familiar y Comunitaria/tendencias , Asesoramiento Genético , Enfermedades Genéticas Congénitas/diagnóstico , Técnicas Genéticas/tendencias , Pruebas Genéticas , Terapia Genética , Humanos , Recién Nacido , Mala Praxis , Tamizaje Neonatal , Rol del Médico , Diagnóstico PrenatalRESUMEN
When the full-length coat protein (CP) of the potyvirus, Johnsongrass mosaic virus (JGMV), was expressed in Escherichia coli or yeast, it assembled to form potyvirus-like particles. The particles were heterogeneous in length with a stacked-ring appearance and resembled JGMV particles in their flexuous morphology and width. This cell-free assembly system should permit analysis of the mechanisms of particle assembly and genome encapsidation. Two mutant forms of CP produced by site-directed mutagenesis failed to assemble into virus-like particles.