RESUMEN
BACKGROUND: Multiple primary malignancies (MPM) have become increasingly prevalent worldwide. This investigation was aimed at establishing the clinicopathological characteristics of MPM patients and evaluating the impact of the living environment on MPM in the Taiwanese population. MATERIALS AND METHODS: From January 2009 to December 2013, a total of 8,268 cancer patients were identified in our institutional center. Of these, 125 were diagnosed as MPM and thus enrolled. Data for clinicopathological features and treatment approaches for these MPM patients living in urban or suburb zone were obtained. Findings for the air pollution status in Taiwan were also collected. RESULTS: The most common cancer match of MPM was esophageal cancer with hypopharyngeal cancer (12.8%), followed by colorectal cancer with gastric cancer (6.4%) and colorectal cancer with breast cancer (5.6%). The air quality was significantly worse in the urban than in the suburban zone and there was a remarkably higher portion of MPM patients in the urban zone suffering from grade III and IV post-chemotherapeutic neutropenia (30.8% vs 15.1%, P=0.036). CONCLUSIONS: The tumor frequency and site distribution should be taken into the clinical evaluation because there is a relatively high risk of developing MPM. This study also highlighted the potential influence of environmental factors on post-chemotherapeutic neutropenia for patients with MPM.
Asunto(s)
Contaminación del Aire/estadística & datos numéricos , Consumo de Bebidas Alcohólicas/epidemiología , Neoplasias Primarias Múltiples/epidemiología , Neutropenia/epidemiología , Características de la Residencia/estadística & datos numéricos , Fumar/epidemiología , Población Suburbana/estadística & datos numéricos , Población Urbana/estadística & datos numéricos , Antineoplásicos/efectos adversos , Neoplasias de la Mama/epidemiología , Neoplasias de la Mama/terapia , Neoplasias Colorrectales/epidemiología , Neoplasias Colorrectales/terapia , Neoplasias Esofágicas/epidemiología , Neoplasias Esofágicas/terapia , Femenino , Humanos , Neoplasias Hipofaríngeas/epidemiología , Neoplasias Hipofaríngeas/terapia , Masculino , Persona de Mediana Edad , Neoplasias Primarias Múltiples/terapia , Neutropenia/inducido químicamente , Prevalencia , Estudios Retrospectivos , Factores de Riesgo , Neoplasias Gástricas/epidemiología , Neoplasias Gástricas/terapia , Taiwán/epidemiologíaRESUMEN
BACKGROUND: The prevalence of esophageal cancer (EC) with second primary cancers (SPC) is increasing worldwide. This study was aimed to understand the clinical features of EC patients with SPC in the Taiwanese population. MATERIALS AND METHODS: Clinical and laboratory data for 180 EC patients with or without SPC were collected between January 2009 and December 2013. Information on treatment approaches, location of SPCs and ABO blood type were also collected and stratified. RESULTS: The most common SPC in EC patients was hypopharyngeal cancer, followed by laryngeal cancer and hepatocellular carcinoma in our study. Malignancies of colon, prostate and lung were also found. There was a significant higher portion of blood type A in the EC patients with SPC compared with those without (42.4% vs 19.5%, P=0.006). CONCLUSIONS: The frequency and SPC site distribution and blood type A should be considered in clinical evaluation of EC patients with a high risk of developing SPC in the Taiwanese population.