Asunto(s)

Ceftriaxona/efectos adversos , Hemólisis/efectos de los fármacos , Enfermedad Aguda , Preescolar , Resultado Fatal , Femenino , Humanos

RESUMEN

A cytogenetically normal infant with Kostmann syndrome (severe congenital granulocytopenia) was treated with granulocyte colony-stimulating factor, which resulted in a rapid improvement in his neutrophil count and a resolution of recurrent infections. After 11 months of therapy, splenomegaly developed, with thrombocytopenia, anemia, circulating nucleated erythrocytes, and acquired monosomy 7, which evolved during a period of 7 months into acute nonlymphoblastic leukemia. The use of granulocyte colony-stimulating factor in patients with congenital marrow failure disorders may induce or hasten the onset of a malignant transformation.

Asunto(s)

Cromosomas Humanos Par 7/efectos de los fármacos , Factor Estimulante de Colonias de Granulocitos/efectos adversos , Leucemia Mieloide Aguda/etiología , Monosomía/diagnóstico , Neutropenia/congénito , Enfermedad Crónica , Factor Estimulante de Colonias de Granulocitos/administración & dosificación , Humanos , Lactante , Cariotipificación , Leucemia Mieloide Aguda/diagnóstico , Masculino , Neutropenia/complicaciones , Neutropenia/terapia , Factores de Tiempo