RESUMEN
A synchronous-traveling carrier photodetector (STC-PD) with a thick absorption region and large diameter is presented and investigated for 100 Gbps PAM4 applications. In the STC structure, a suitable electric field is introduced to synchronize the traveling of electrons and holes, which achieves high bandwidth while maintaining large responsivity. The characteristics of STC-PD, including electric field distribution, energy band diagram, responsivity, junction capacitance, and frequency response, have been studied carefully.
RESUMEN
We demonstrate a new, to the best of our knowledge, dimensional "horizontal optimization" scheme, which can improve the high-speed characteristics of a PIN photodetector by designing the incident optical field distribution. First, coaxially incident faculae with the same peak and same power are studied and simulated, revealing that the bandwidth of the photodetector illuminated by uniform light is higher than that of the device illuminated by nonuniform light. Next, an annular optical field is designed incident to the photodetector, and the bandwidth is further improved. For a PIN photodetector, by carefully optimizing the incident optical field distribution, the photodetector bandwidth under an annular optical field can be increased significantly compared with that under conventional coaxial illumination.
RESUMEN
At present, there is no specific antidote for colchicine intoxication, and 0.8 mg/kg is its lethal dose.The prognosis of colchicine intoxication patients is closely related to the dosage, but the individual difference is very great. A 38-year-old man with colchicine poisoning was admitted to the Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, who had ingested 80 mg colchicine tablets (1.19 mg/kg) orally for 4 hours. He was immediately put on gastric lavage, enema, and catharsis. Continuous blood purification was performed for 34 hours and 22 minutes, with a combination of hemoperfusion (HP) and continuous veno-venous hemofiltration dialysis (CVVHDF). He also received a large dose of the glucocorticoid with 80 mg of methylprednisolone injected intravenously every 8 hours and organ function support. The patient was hospitalized for 2 weeks and discharged with improvement. The successful treatment of this case was reported for reference.
RESUMEN
Four stereoisomers 1a-d of cis-fluoro-ohmefentanyl have been synthesized. Their absolute configurations were determined by X-ray analysis of (3S,4R,2'S)-(-)-cis-I d. The analgesic activity (mice, sc, hot plate) revealed extreme stereodifferences. The ED50 value of (3R,4S,2'S)-(+)-cis-I (1a) was 0.000774 mg/kg (17958 times more potent than that of morphine), while the corresponding antipode 1c was almost inactive.