RESUMEN

Aim: This study was intended to establish the reference intervals of bone turnover markers (BTMs) for healthy populations. Methods: According to the Clinical Laboratory Standards Institute (CLSI) EP28-A3c, we recruited 774 healthy Chinese and investigated their clinical characteristics and relationships among gender, age, season and BTMs. The reference intervals of BTMs for healthy populations in Hebei of China were established through defining the central 95% range of all observations. Results: We found that gender were associated with 25(OH)D, OC, ß-CTX, and P1NP (P < 0.05), but not PTH1-84 (P=0.138). All serum BTMs showed differences among different age groups (P < 0.01). The level of 25 (OH) D in winter showed statistical differences with spring, summer, and autumn (P<0.05). The OC level showed statistical difference between summer and winter (P=0.000). The P1NP levels showed statistical difference between spring and winter (P=0.019), summer and winter (P=0.000), and summer and autumn (P=0.012), respectively. The PTH1-84 levels in winter showed statistical differences with spring, and summer (all P=0.000), while there was no statistically significant difference in ß- CTX levels between seasons. Conclusion: We have established the reference intervals of several BTMs for healthy individuals in Hebei of China, which have statistical significance across different age groups and genders, and there are also significant differences between different seasons. Therefore, the Chinese medical laboratories in different locations should group individuals according to gender and age groups in different seasons, and establish corresponding biological reference intervals.

RESUMEN

Purpose: To evaluate serum cortistatin (CST) levels in type 2 diabetes mellitus (T2DM) patients with or without non-alcoholic fatty liver disease (NAFLD) and to examine the relationship between CST and NAFLD. Methods: A total of 90 T2DM patients, which included 56 NAFLD patients (referred to as DM+NAFLD group) and 34 patients without NAFLD (DM-only group), and 83 non-diabetes individuals that included 39 NAFLD patients (NAFLD-only group) and 44 without NAFLD that acted as the normal-control group (NC group). The differences in the serum CST levels between the groups were compared, and the correlations between CST and other variables were calculated by applying both correlational analysis and multiple linear regression analysis. Results: The mean serum CST levels were significantly lower in the DM+NAFLD and DM groups than in the NC group (P < 0.05). In addition, the CST levels were lower in the DM group relative to that in the NAFLD group (P < 0.05). However, no statistical difference was noted in the serum CST between diabetic patients with and without NAFLD (P > 0.05). Similarly, in the non-diabetic group, the serum CST level was not significantly different between individuals with and without NAFLD (P > 0.05). Furthermore, the serum CST levels were negatively associated with the levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), fasting plasma glucose (FPG), homeostasis model assessment-insulin resistance (HOMA-IR), and insulin cell function index (HOMA-ß). Conversely, the serum CST levels were positively associated with high-density lipoprotein cholesterol (HDL-C). The data obtained through multiple linear regression implied that LDL-C and HOMA-ß, but not HOMA-IR, were closely related to serum CST levels. Conclusion: T2DM was related to decreased serum CST. However, serum CST was correlated with HOMA-ß in T2DM patients, while HOMA-IR was not. There was no correlation between CST and NAFLD.

RESUMEN

Three complexes of M(DPIP)2 (M=Cu, Co, Zn as 1, 2, 3) were synthesized and characterized by elemental analysis, IR, UV-Vis, thermogravimetry, and X-ray diffraction. Their nonlinear optical properties were measured by the Z-scan technique and yielded a normalized transmittance of about 70% for complex 1 (45 µJ pulse), and 93% for complex 3 (68 µJ pulse at the focus point). The nonlinear absorption coefficient, ß, is 1.4×10(-11) m/W for 1 and 5.6×10(-13) m/W for 3, and the third-order nonlinear refraction index, n2, is 1.0×10(-18) m(2)/W for 3. Complex 1 shows self-defocusing property, while complex 3 exhibits self-focusing property. The thermogravimetric results show that the frame structure of compounds 1-3 begin to collapse at 400, 250 and 280°C, respectively, which suggests that they elicit excellent thermal stability. This research aims to provide better understanding of these compounds, and offer preliminary explanations for the significant differences between compounds 1-3, in order to potentially help in the designing of future novel materials with NLO properties.

Asunto(s)

RESUMEN

Vibrational spectral measurements were made for 9-anthracenemethanol. Optimized geometrical structure and harmonic vibration frequencies were computed based on ab initio and density functional theory B3LYP methods using 6-311G(**) and LANL2DZ basis sets. The equilibrium geometries got from all of the methods and basis were compared with X-ray diffraction results. The IR and UV-vis spectra of the title compound were computed using all of the methods and choose the most appropriate way to discuss. And the absorption spectra were calculated both in gas phase and in CH(3)CH(2)OH and CH(3)CN solution. The calculated results matched well with the experimental values. On the basis, the first excited state electronic transition energy has been calculated using time-dependent density functional theory.

Asunto(s)

RESUMEN

In the title salt, {[Ho(NO(3))(2)(C(6)H(18)N(3)OP)(4)][AgWS(4)]}(n), the anion forms a W/S/Ag polymeric chain along the a axis. The holmium atom in the cation is coordinated by eight O atoms from two nitrate and four hexa-methyl-phospho-ramide ligands in a distorted square-anti-prismatic geometry. Together with the two nitrate ligands, the complex cation in the title compound is univalent, which leads the anion to be univalent as well. The polymeric anionic chain with W-Ag-W and Ag-W-Ag angles of 161.429 (17) and 153.608 (10) °, respectively, presents a distorted linear configuration. The title complex is isotypic with the corresponding Y, Yb, Eu, Nd, La and Dy analogues.

RESUMEN

The title compound, C(17)H(13)N(3)OS, was obtained by the reaction of benzoyl chloride, ammonium thio-cyanate and 5-amino-quinoline in the presence of polyethyl-eneglycol-400 (PEG-400) as a phase-transfer catalyst. The compound crystallized as discrete mol-ecules linked by N-H⋯N and C-H⋯N hydrogen bonds involving all the potential donors, generating sheets parallel to (100). An intramolecular N-H⋯O bond is also present.

RESUMEN

IN THE ZWITTERIONIC TITLE COMPOUND (SYSTEMATIC NAME: 4-{[amino(inimio)methyl]amino}benzenesulfonate), C(7)H(9)N(3)O(3)S, the dihedral angle between the plane of the guanidine grouping and the benzene ring system is 44.87 (7)°. The crystal packing is stabilized by inter-molecular N-H⋯O hydrogen bonds involving all the potential donors.

RESUMEN

The title compound, C(10)H(11)N(4) (+)·Cl(-), has been synthesized by the reaction of 8-amino-quinoline and cyanamide. The dihedral angle between the plane of the guanidine group and the quinoline ring system is 68.64 (13)°. The crystal structure is stabilized by inter-molecular N-H⋯Cl hydrogen bonds.