1.
Bioorg Med Chem Lett
; 12(20): 2875-8, 2002 Oct 21.
Artículo
en Inglés
| MEDLINE
| ID: mdl-12270167
RESUMEN
A library of benzofurans was prepared by solid-phase synthesis methods, and several analogues were identified as potent ligands for the estrogen receptors ER-alpha and ER-beta, with some compounds having selectivity for ER-alpha. Analogues designed to more closely mimic Raloxifene were less effective. Certain benzofurans were effective in a bone pit assay, but were characterized as agonists in a MCF-7 breast tumor cell proliferation assay.