RESUMEN
A presença de anticorpos contra o antígeno-T produzido por vírus BK foi testada no soro e urina de pacientes com transplante de medula óssea e em controles. Nenhum paciente com transplante, nem com anemia aplástica ou leucemia, desenvolveu anticorpos antiantígeno T, indicando ausência de um papel etiológico do vírus BK ( um polioma humano) em leucemia ou anemia aplástica
Asunto(s)
Preescolar , Niño , Adolescente , Adulto , Persona de Mediana Edad , Humanos , Masculino , Femenino , Anemia Aplásica/etiología , Virus BK/análisis , Leucemia/etiología , Antígenos Virales de Tumores/orina , Médula Ósea/trasplanteAsunto(s)
Complicaciones Infecciosas del Embarazo , Virosis , Animales , Anticuerpos Antivirales/análisis , Varicela/prevención & control , Anomalías Congénitas/etiología , Infecciones por Citomegalovirus/prevención & control , Femenino , Enfermedades Fetales/etiología , Hepatitis B/complicaciones , Herpes Simple/complicaciones , Humanos , Papillomaviridae , Polyomaviridae , Embarazo , Complicaciones Infecciosas del Embarazo/prevención & control , Viruela/complicaciones , Infecciones Tumorales por Virus/complicaciones , Virosis/complicaciones , Virosis/prevención & controlRESUMEN
126 children of 102 hepatitis B surface antigen (HBsAg) carrier mothers were delivered at Hammersmith Hospital and Queen Charlotte's Maternity Hospital, between 1971 and mid-1978. Blood tests on 110 of these children showed that 8 out of the 18 with Chinese mothers, but only 6 out of the 92 other children, have become HBsAg positive. The presence of maternal hepatitis B e antigen (HBeAg) is also significantly correlated with transmission of HBsAg to the children. The management of children whose mothers are carriers is discussed.
Asunto(s)
Portador Sano , Hepatitis B/transmisión , Intercambio Materno-Fetal , Portador Sano/inmunología , Preescolar , Etnicidad , Femenino , Sangre Fetal/inmunología , Hepatitis B/inmunología , Antígenos de Superficie de la Hepatitis B/análisis , Humanos , Lactante , Londres , Masculino , Embarazo , Complicaciones Infecciosas del Embarazo/transmisiónRESUMEN
Fifty patients with congestive cardiomyopathy have been studied for evidence of previous Coxsackie B virus infection and compared with age- and sex-matched controls who had been admitted to hospital for investigation of other cardiac diseases. High neutralisation titres (greater than or equal to 1024) to Coxsackie B viruses were more common among the controls. On subdividing the patients according to their length of symptomatic history before study, high titres were more common only in those with a short history (less than or equal to 1 year). High titres were more common when there had been a febrile illness at the onset of symptoms. Endomyocardial biopsies of 18 patients disclosed no evidence of myocarditis, or, in 12 cases, of viral involvement. Although the evidence remains circumstantial, these results support the theory that Coxsackie B viruses may cause congestive cardiomyopathy and encourage further research into the mechanisms of myocardial cell damage by these visuses.
Asunto(s)
Anticuerpos Antivirales/análisis , Cardiomiopatías/inmunología , Enterovirus Humano B/inmunología , Adulto , Cardiomiopatías/etiología , Infecciones por Coxsackievirus/complicaciones , Femenino , Antígenos HLA/análisis , Humanos , Masculino , Pruebas de NeutralizaciónRESUMEN
In a period of six years (1971--77) 9400 sera taken at booking from antenatal patients were examined for hepatitis B antigen (HBsAg), and 40 patients were positive. These 40 patients had 45 pregnancies and were treated with special precautions so far as venepuncture and the management of delivery were concerned. No member of the hospital staff dealing with the patients developed hepatitis B. All infants born to these mothers were normal, two infants were HBsAg-positive at 7 months and 2 years, but are clinically well. No obstetric problems attributable to the HBsAg-positive state were encountered.
Asunto(s)
Portador Sano , Antígenos de la Hepatitis B/análisis , Complicaciones Infecciosas del Embarazo/inmunología , Adolescente , Adulto , Femenino , Hepatitis B/prevención & control , Humanos , EmbarazoRESUMEN
Hepatitis B is a hazard in anaesthetic practice because the virus is carried in the blood, and operative, investigative or obstetric procedures involve the shedding of blood. A list is given of classes of potential carrier, who should be tested for hepatitis B antigen (HBAg), and a procedure is outlined for minimizing the risk to staff engaged on surgical operations on hepatitis carriers. The carrier state in a patient is not regarded as a contraindication to any necessary operation, nor, in a doctor, to the practice of medicine.
Asunto(s)
Anestesiología , Infección Hospitalaria/prevención & control , Infección Hospitalaria/transmisión , Hepatitis B/prevención & control , Procedimientos Quirúrgicos Operativos , Portador Sano , Desinfección/métodos , Hepatitis B/diagnóstico , Hepatitis B/transmisión , Humanos , Cuerpo Médico de Hospitales , Equipo Quirúrgico , Instrumentos QuirúrgicosAsunto(s)
Hepatitis A/microbiología , Hepatitis B/microbiología , Hepatovirus/aislamiento & purificación , Animales , Anticuerpos Antivirales , Callitrichinae , Heces/microbiología , Gastroenteritis/microbiología , Hepatitis A/diagnóstico , Hepatitis A/transmisión , Hepatitis B/inmunología , Antígenos de la Hepatitis B/análisis , Virus de la Hepatitis B/aislamiento & purificación , Hepatovirus/ultraestructura , Humanos , Hígado/microbiología , Parvoviridae/aislamiento & purificación , Virus no Clasificados/aislamiento & purificaciónRESUMEN
Hepatitis B virus still cannot be grown in an in vitro system; therefore, research into hepatitis B antigen (HB Ag) is limited to laboratory methods such as serology, electron microscopy, and biochemistry. These have established the presence of two distinct antigenic components of HB Ag, that associated with the small forms and the outer covering of the Dane particle (HBs Ag), and that of the Dane particle core (HBc Ag). Current findings make it almost certain that the Dane particle represents the hepatitis B virus (HBV), the smaller forms of the antigen representing excess viral lipoprotein. The group of individuals positive for the antigen are considered and the immunopathology of the disease is discussed. Present understanding of the antigen has made it possible to consider the use of HBs Ag as a means of vaccination. However, further information on the immune mechanisms associated with HB Ag are required before this can be accepted as a general means of protection. Finally, looking at currently available techniques, it would appear that passive hemagglutination and radioimmunoassay are both highly specific and sensitive methods of screening for HB Ag.