Asunto(s)
Antineoplásicos Fitogénicos/aislamiento & purificación , Plantas Medicinales/análisis , Alcaloides de Pirrolicidina/aislamiento & purificación , Animales , Carcinoma de Ehrlich/tratamiento farmacológico , Cromatografía en Capa Delgada , Egipto , Ratones , Extractos Vegetales/análisis , Extractos Vegetales/farmacología , Alcaloides de Pirrolicidina/farmacologíaRESUMEN
A double-blind study has been performed to search for the possible effect of khellin in psoriasis. 10 patients were treated orally with khellin and subsequently exposed to sunlight for 4 months; a total of 8 cases responded positively with variable degrees of clearance. None of 10 controls had any response. A relapse-free duration of 3 years was recorded for 6 out of the 8 responders. This study would introduce the nonpsoralen compound khellin as a possible agent for the therapy of psoriasis.
Asunto(s)
Khellin/administración & dosificación , Psoriasis/tratamiento farmacológico , Adolescente , Adulto , Método Doble Ciego , Femenino , Helioterapia , Humanos , Masculino , Persona de Mediana EdadRESUMEN
An anticipated effect of khellin, related to its chemical structure, in the photochemotherapy of amelanosis has been investigated. In a double-blind clinical study, khellin has been orally administered to 30 vitiligo patients for 4 months with subsequent exposure to natural sunlight. At the end of the trial period, 5 patients out of 30 (16.6%) repigmented 90-100%; 7 cases (23.3%) repigmented 50-60% of the vitiliginous areas treated; 11 (36.6%) repigmented 25% or less, and 7 subjects (23.3%) showed negative response. 30 control subjects failed to repigment at all. The achieved repigmentation was stable after drug cessation for a period of 1 year. These data add a previously unreported effect for the non-psoralen compound, khellin, in the therapy of vitiligo.