1.
DNA Seq
; 10(2): 133-7, 1999.
Artículo
en Inglés
| MEDLINE
| ID: mdl-10376217
RESUMEN
Caspases are a family of cysteine proteases which have important roles in activation of cytokines and in apoptosis. Caspase-1, or interleukin-1 beta converting enzyme (ICE), promotes maturation of interleukin-1 beta (IL-1 beta) and interleukin-18 (IL-18) by proteolytic cleavage of precursor forms to generate biologically active peptides. We report the cloning and sequencing of equine caspase-1 cDNA. Equine caspase-1 is 405 amino acids in length and has 72% and 63% identity to human and mouse caspase-1, respectively, at the amino acid level. Sites of proteolytic cleavage and catalytic activity as identified in human caspase-1, are conserved.
Asunto(s)
Caspasa 1/genética , Equidae , Secuencia de Aminoácidos , Animales , Secuencia de Bases , ADN Complementario , Humanos , Ratones , Datos de Secuencia Molecular
2.
Am J Clin Pathol
; 58(3): 275-80, 1972 Sep.
Artículo
en Inglés
| MEDLINE
| ID: mdl-5075110