RESUMEN
A 28-year-old, previously healthy mother of one child, with cigarette smoking and oral contraceptive medication as only risk factors suffered an acute anterior myocardial infarction without prior anginal complaints. Angiographically there were thrombotic occlusions of the LAD after the first septal branch and also of the distal left circumflex coronary artery. Six days after catheter recanalisation of the LAD and i.e. infusion of urokinase, there were small residual thrombi in the otherwise perfectly normal LAD and in a diagonal branch whereas the circumflex coronary artery was completely normal. The left ventricle showed anteroseptal (but not inferior) akinesis. The case report supports the hypothesis that myocardial infarctions under oral contraceptive medication are a separate disease entity unrelated to coronary atherosclerosis and may be the consequence of a "coagulation accident".
Asunto(s)
Anticonceptivos Sintéticos Orales/efectos adversos , Angiografía Coronaria/efectos de los fármacos , Trombosis Coronaria/inducido químicamente , Desogestrel/efectos adversos , Adulto , Anticonceptivos Sintéticos Orales/administración & dosificación , Trombosis Coronaria/diagnóstico por imagen , Trombosis Coronaria/tratamiento farmacológico , Desogestrel/administración & dosificación , Femenino , Humanos , Factores de Riesgo , Fumar/efectos adversos , Terapia Trombolítica , Activador de Plasminógeno de Tipo Uroquinasa/administración & dosificaciónRESUMEN
We report on the organisation of developing a bone marrow donor file. Emphasis was placed on adequate information for and informed consent and on adherence to legal requirements for maintaining confidentiality. Nearly 7500 blood donors received a three part information, including the possibility of registration as a potential bone marrow donor. About 430 donors are now registered in this bone marrow donor file.
Asunto(s)
Trasplante de Médula Ósea/métodos , Bases de Datos Bibliográficas/legislación & jurisprudencia , Donantes de Tejidos/legislación & jurisprudencia , Confidencialidad/legislación & jurisprudencia , Alemania , Humanos , Educación del Paciente como Asunto/legislación & jurisprudencia , Obtención de Tejidos y Órganos/legislación & jurisprudenciaRESUMEN
We report on a multigravida with high-titer Rh-incompatibility who was admitted for delivery at term. Multiple intrauterine transfusions had resulted in nearly total replacement of fetal cells with donor cells. Routine serologic methods were unable to determine the blood group of the newborn and resulted in a falsely negative direct antiglobulin test. Four weeks later the newborn developed severe anemia in need of transfusion. The anemia was explained by a) suppression of erythropoesis because of early optimization of tissue oxygenization with the prenatally transfused HbA-containing donor cells, b) their limited survival in the infant and c) the accelerated elimination of the baby's own red cells by the maternal antibody.