RESUMEN
Polybrominated diphenyl ethers (PBDEs) are becoming a public health concern because of their potential toxicity, from endocrine disruption system to neurodevelopmental impairments. Nonetheless, information on their levels in human blood is scarce. In this study, human serum samples collected in Shanghai, China, were analyzed for the concentrations of PBDEs and their hydroxylated metabolites (OH-PBDEs). Eight PBDE congeners and six OH-PBDE congeners were quantified in serum samples by gas chromatography with mass spectrometry (GC-MS) and high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). As a result, total PBDE concentration ranged from 0.280 to 12.330 ng g-1 on a lipid weight basis lw (median: 1.100 ng g-1 lw) and the total OH-PBDE level ranged from 0.045 to 0.363 ng g-1 (lw) (median: 0.187 ng g-1 lw). Among them, BDE-47 and 6-OH-BDE-47 were the predominant PBDEs and OH-PBDEs, respectively. In addition, based on the results of the Bartelett X 2 test, BDE-47 significantly (p < 0.05) correlated with BDE-28, BDE-100, BDE-85, and BDE-154, whereas 3'-OH-BDE-7 significantly (p < 0.01) correlated with 3-OH-BDE-47, 2-OH-BDE-68, and 6'-OH-BDE-99. Among all donors, no significant association between age and PBDEs (or OH-PBDEs) was found. Further research on the exposure routes in the environment and metabolic processing of PBDEs in human blood is necessary.
Asunto(s)
Disruptores Endocrinos/sangre , Monitoreo del Ambiente/métodos , Contaminantes Ambientales/sangre , Éteres Difenilos Halogenados/sangre , Bifenilos Polibrominados/sangre , Adulto , China , Monitoreo del Ambiente/instrumentación , Humanos , Hidroxilación , Espectrometría de Masas en TándemRESUMEN
Herein, we studied the occurrence and profiles of thirteen PBDE congeners in 30 river sediment samples from Shanghai, China. The concentrations of Σ13PBDEs ranged from 110 to 13,071 pg g -1 dw, with an average value of 2,841 pg g -1 dw. BDE-209 was the predominant congener accounting for more than 65 % of total PBDEs, demonstrating that the major source of PBDEs in sediment samples was associated with the prevalent use of technical deca-BDE products. Moreover, low brominated BDEs in sediments also came from the degradation of higher brominated BDEs. In addition, taking into consideration of dietary exposure, PBDEs in serum samples collected from the locals were also detected with range of 419-26,744 pg g-1 (average 5,561 pg g -1), which suggested a relatively low burden of PBDEs contamination to human body compared with the condition in other place. And in serum, low brominated compounds constituted the majority of total PBDE congeners.
Asunto(s)
Sedimentos Geológicos/análisis , Éteres Difenilos Halogenados/análisis , Ríos/química , China , Monitoreo del Ambiente , Sedimentos Geológicos/química , Éteres Difenilos Halogenados/sangre , HumanosRESUMEN
Perfluorinated compounds (PFCs) have potential health risk to human. In this paper, human serum samples collected from Jiading District, Shanghai aged from 23 to 87 years old (12 male and 33 female) were analyzed for 17 perfluorinated compounds (PFCs). A novel method for the elimination of background contamination of perfluorooctanoic acid (PFOA) generated from instrument by the modification of high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) has also been developed and validated. The limit of detection (LOD) for all monitored PFCs range from 0.02 to 0.18 ng mL-1. The limit of quantitation (LOQ) for PFOS and PFOA was 2.23 and 1.60 ng mL-1, respectively, and for other PFCs it ranged from 0.04 to 0.88 ng mL-1. Of the 17 PFCs analyzed in Shanghai serum, eleven were found. The dominating PFCs in all samples were perfluorooctanesulfonate (PFOS) and PFOA with a fraction of 49.5%, 34.2%, respectively. The median total concentration of each serum samples was 53.43 ng mL-1 with a range from Asunto(s)
Cromatografía Líquida de Alta Presión/métodos
, Contaminantes Ambientales/sangre
, Contaminación de Equipos/prevención & control
, Fluorocarburos/sangre
, Espectrometría de Masas en Tándem/métodos
, Adulto
, Factores de Edad
, Anciano
, Anciano de 80 o más Años
, Ácidos Alcanesulfónicos/sangre
, Caprilatos/sangre
, China
, Cromatografía Líquida de Alta Presión/normas
, Ciudades
, Femenino
, Humanos
, Límite de Detección
, Masculino
, Persona de Mediana Edad
, Análisis de Componente Principal
, Control de Calidad
, Espectrometría de Masas en Tándem/normas
, Adulto Joven