RESUMEN
BACKGROUND: This study aims to evaluate the efficacy and safety of montelukast for the treatment of patients with pediatric allergic purpura (PAP). METHODS: We will retrieve the following electronic databases from inception to the present: MEDILINE, Embase, CENTRAL, CINAHL, AMED, Chinese Biomedical Literature Database, China National Knowledge Infrastructure Database, Wanfang, and VIP database without language limitation. Two authors will carry out study selection, data extraction, and quality evaluation independently. RevMan V5.3 software will be used for statistical software. RESULTS: This study will summarize high-quality evidence-based medicine to evaluate the efficacy and safety of montelukast for the treatment of PAP. CONCLUSION: This study will provide strong evidence to determine whether montelukast is an effective and safety treatment for PAP. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42019145472.
Asunto(s)
Acetatos/uso terapéutico , Vasculitis por IgA/tratamiento farmacológico , Quinolinas/uso terapéutico , Revisiones Sistemáticas como Asunto , Niño , Ciclopropanos , Femenino , Humanos , Masculino , Proyectos de Investigación , Sulfuros , Resultado del TratamientoRESUMEN
MIL-88A@MIP was fabricated for the first time in this experiment with a metal-organic framework of MIL-88A as the precursor based on the molecular imprinting method. It was characterized by X-ray diffraction (XRD), scanning electronic microscopy (SEM), energy dispersive spectrometer (EDS), and N2 adsorption. The catalytic performance of MIL-88A@MIP was tested to activate persulfate (PS) to generate SO4-· for the degradation of dibutyl phthalate (DBP), which was used as a target pollutant. Compared with the precursor MIL-88A, the catalytic activity of MIL-88A@MIP was improved effectively through targeted modification, and the DBP removal rate increased 80.4% after reacting for 480 min. An experiment determining the influencing factors showed that the optimum activation condition of the catalyst was PS:DBP=600:1, MIL-88A@MIP dosage of 0.5 g·L-1,and pH=3.26. Furthermore, MIL-88A@MIP shows a high capability of removing different phthalic acid ester (PAE) contaminants that reflect its targeting selectivity.