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Introduction: With the rapid rise of the gig economy globally, its characteristics of promoting employment and facilitating autonomy have supported its rapid growth and development in China. While the flexibility of gig work offers more employment options and income sources for workers, it also caused many problems and uncertainties. Workplace well-being is an important psychological factor that indicates the psychological state of workers and significantly predicts their behavior at work. However, previous studies on the gig economy rarely analyze gig workers' workplace well-being, which is of great significance to improving their individual emotions, promoting their physical and mental health, and maintaining the sustainable development of the gig economy and society in general. Methods: This study draws on the cognitive-affective processing system framework to construct a moderated dual-mediator model to explore the dual influence mechanism of job autonomy on gig workers' workplace well-being. Based on the data of 442 digital gig workers who were mainly engaged in manual labor. Results: The survey results show that job autonomy positively affects employees' workplace well-being, and work alienation and positive emotion mediate this relationship. Perceived algorithmic control can moderate not only the influence of job autonomy on work alienation and positive emotion but also the indirect impact of job autonomy on workplace well-being through work alienation and positive emotion. Discussion: The finding of this research contributes to expand the comprehension of the relationship between gig-worker job autonomy and workplace wellbeing and this relationship's underlying mechanism, holding significant implications for management practice.

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The defect structure, spin Hamiltonian parameters (SHPs: anisotropic g factors g ‖ and g ⊥ and the hyperfine structure constants A ‖ and A ⊥ ), and their compositional dependence of Cu 2 + in x CuO - ( 68 - x ) V 2 O 5 - 32 TeO 2 ( x = 5, 10, 20, 30 mol%) glasses are quantitatively analyzed by using the higher-order perturbation formula of octahedral complex with tetrahedral elongation distortion. Due to the Jahn-Teller effect, the [ CuO 6 ] 10 - group is subjected to tetragonal elongation distortion of varying degrees. D q , N , ρ , κ , and H show nonlinear changes with the concentrations of Cu 2 + . When x = 10 mol% CuO, the degree of distortion ( ρ ≈ 0 . 1 % ) is the smallest; when x = 30 mol% CuO, the degree of distortion ( ρ ≈ 15 % ) is the largest, which indicates that excessive distortion leads to the appearance of Z -axis oxygen vacancies and the coordination number of copper ions from six to four. The increasing tendency of the evaluated N and H reveals decreasing covalency of the whole glass system. Present theoretical studies would be useful to the explore the structural properties and optical applications of glass with different CuO concentrations.

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When using ab initio methods to obtain high-quality quantum behavior of molecules, it often involves a lot of trial-and-error work in algorithm design and parameter selection, which requires enormous time and computational resource costs. In the study of vibrational energies of diatomic molecules, we found that starting from a low-precision DFT model and then correcting the errors using the high-dimensional function modeling capabilities of machine learning, one can considerably reduce the computational burden and improve the prediction accuracy. Data-driven machine learning is able to capture subtle physical information that is missing from DFT approaches. The results of 12C16O, 24MgO and Na35Cl show that, compared with CCSD(T)/cc-pV5Z calculation, this work improves the prediction accuracy by more than one order of magnitude, and reduces the computation cost by more than one order of magnitude.

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Self-serving leadership is a typical example of destructive leadership that has negative effects on its subordinates and organization. According to social identity theory, we propose a theoretical model that self-serving leadership induces employee interpersonal deviance and organizational deviance through organization identification, and we explore the moderating role of moral identity in this relationship. Based on survey data collected from 377 questionnaires by using a three-wave time lagged design, structural equation modeling results showed that (1) there was a significant positive correlation between self-serving leadership and employees' deviant behavior, (2) organizational identification partially mediates the relationship between self-serving leadership and employees' deviant behavior, and (3) employees' moral identity negatively moderates the relationship between self-serving leadership and employees' organizational identification. The findings further extend the research on the influence of self-serving leadership on employee workplace deviance. They also reveal the mechanisms and boundary conditions of the effect of self-serving leadership on employee workplace deviance.

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Employee innovative behavior is significant in maintaining an organization's sustainable development. This study explored the impact of team psychological safety and workplace anxiety on the association between self-serving leadership and employee innovation behavior by synthesizing social information processing theory, conservation of resources theory, and ego depletion theory. We conducted a hierarchical linear model analysis using three-wave paired data collected from 86 leaders and 392 employees. The research results showed that self-serving leadership is negatively correlated with employee innovation behavior. Meanwhile, team psychological safety and workplace anxiety mediated this relationship. In addition, team psychological safety mitigates the impact of workplace anxiety on employee innovation behavior and the indirect impact of self-serving leadership on employee innovation behavior via workplace anxiety. These findings have a number of theoretical and practical implications in the domains of self-serving leadership and employee innovation behavior.

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BACKGROUND: Plants remain an important source of new drugs, new leads and new chemical entities. Triptolide is a diterpenoid epoxide isolated from Tripterygium wilfordii Hook F that possesses a broad range of bioactivities, including anti-inflammatory, immunosuppressive and anti-tumor properties. The antiviral activity of triptolide against human immunodeficiency virus type 1 (HIV-1) has not been reported. RESULTS: In this study, nanomolar concentrations of triptolide were shown to potently inhibit HIV-1 replication in vitro. To identify the step(s) of the HIV-1 replication cycle affected by triptolide, time-of-addition studies, PCR analysis and direct transfection of viral genomic DNA were performed. The results of these experiments indicated that triptolide acts at the stage of viral gene transcription. In addition, a luciferase-based reporter assay that allows quantitative analysis of long terminal repeat (LTR)-driven transcription showed that Tat-induced LTR activation was impaired in the presence of triptolide. Moreover, Western blot analysis of exogenous gene expression (driven by the human elongation factor 1 α subunit promoter) in transiently transfected cells revealed that triptolide specifically reduces the steady-state level of Tat protein, without suppressing global gene expression. Further studies showed that triptolide accelerates Tat protein degradation, which can be rescued by administration of the proteasome inhibitor MG132. Mutation analysis revealed that N-terminal domains of Tat protein and nuclear localization are required for triptolide to reduce steady-state level of Tat. CONCLUSION: This study suggests for the first time that triptolide exerts its anti-HIV-1 activity by specifically prompting the degradation of the virally encoded Tat protein, which is a novel mechanism of action for an anti-HIV-1 compound. This compound may serve as a starting point for developing a novel HIV-1 therapeutic approach or as a basic research tool for interrogating events during viral replication.

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The introduction of highly active antiretroviral therapy has led to a significant reduction in the morbidity and mortality of acquired immunodeficiency syndrome patients. However, the emergence of drug resistance has resulted in the failure of treatments in large numbers of patients and thus necessitates the development of new classes of anti-HIV drugs. In this study, more than 200 plant-derived small-molecule compounds were evaluated in a cell-based HIV-1 antiviral screen, resulting in the identification of a novel HIV-1 inhibitor (fangchinoline). Fangchinoline, a bisbenzylisoquinoline alkaloid isolated from Radix Stephaniae tetrandrae, exhibited antiviral activity against HIV-1 laboratory strains NL4-3, LAI and BaL in MT-4 and PM1 cells with a 50% effective concentration ranging from 0.8 to 1.7 µM. Mechanism-of-action studies showed that fangchinoline did not exhibit measurable antiviral activity in TZM-b1 cells but did inhibit the production of infectious virions in HIV-1 cDNA transfected 293T cells, which suggests that the compound targets a late event in infection cycle. Furthermore, the antiviral effect of fangchinoline seems to be HIV-1 envelope-dependent, as the production of infectious HIV-1 particles packaged with a heterologous envelope, the vesicular stomatitis virus G glycoprotein, was unaffected by fangchinoline. Western blot analysis of HIV envelope proteins expressed in transfected 293T cells and in isolated virions showed that fangchinoline inhibited HIV-1 gp160 processing, resulting in reduced envelope glycoprotein incorporation into nascent virions. Collectively, our results demonstrate that fangchinoline inhibits HIV-1 replication by interfering with gp160 proteolytic processing. Fangchinoline may serve as a starting point for developing a new HIV-1 therapeutic approach.

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Infection by the human immunodeficiency virus (HIV) is characterized by a progressive depletion of CD4 T lymphocytes, which leads to dysfunction of the immune system. Although a variety of mechanisms may contribute to the gradual T cell decline that occurs in HIV-infected patients, abnormal apoptosis of infected or bystander T lymphocytes is an important event leading to immunodeficiency. The HIV envelope glycoprotein plays a crucial role in HIV associated apoptosis through both death receptor-mediated and mitochondria-dependent pathways. This review summarizes current knowledge of Env-mediated T lymphocyte apoptosis.

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OBJECTIVE: To investigate a new way to yield plenty of high purity olfactory ensheathing cells (OECs) and its biocompatibility with appropriate scaffolds. METHODS: OECs were prepared from neonatal Wister rats and co-cultured with poly [LA-co-(Glc-alt-Lys)] (PLGL). Its contact angle, adherent rate, and activity rate were tested. RESULTS: The contact angle of poly (D, L-lactic acid) (PDLLA) (84.5 degree+/-1.5 degree) was significantly higher than that of PLGL (52.6 degree+/-0.8 degree), the adherent rate of PLGL (80%) was significantly higher than that of the PDLLA (57%), and the activity rate of PLGL (88%) was much higher than that of the PDLLA (76%). CONCLUSION: PLGL possesses better hydrophilicity and biocompatibility than PDLLA, and it can provide a better cell growth circumstance which is helpful for the effective treatment of nerve injury.

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