RESUMEN
In the present study, we compare resuscitation of bled sheep with hypertonic saline/dextran or hypertonic saline/hetastarch. Unanesthetized sheep were subjected to 2 h of hemorrhagic hypotension and then resuscitated with 200 ml of 7.5% NaCl solution made up to include either 6% dextran 70 (Macrodex) or 6% hetastarch (Hespan). Both solutions provided an immediate and sustained improvement in arterial pressure and cardiac output. The hypertonic saline/dextran provided a slightly better overall response as mean arterial pressure, cardiac output and central venous pressure were higher in the dextran group at all times post resuscitation. However, only the differences in arterial pressure and initial plasma volume expansion were statistically significant. The somewhat better response to hypertonic saline/dextran may be explained by the higher oncotic pressures generated by dextran compared to equal concentrations of hetastarch.
Asunto(s)
Fluidoterapia/métodos , Resucitación , Choque/terapia , Animales , Dextranos/sangre , Hemodinámica , Soluciones Hipertónicas , Presión Osmótica , Ovinos , Almidón/sangreRESUMEN
We resuscitated unanesthetized bled sheep (bled volume = 1.2-1.7 liters) with 200 ml of hypertonic saline/dextran 70 infused either through a peripheral vein (n = 6) or directly into the red marrow of the sternum (n = 6). Intraosseous infusion of the viscous 7.5% NaCl/6% dextran solution required 2-4 min. Plasma sodium was rapidly increased to the same level in both groups demonstrating equally rapid entry into the vascular space. Both regimens provide rapid and sustained normalization of arterial pressure and cardiac output. No significant differences between the two groups were apparent for any measured variable. Intraosseous infusion of hypertonic resuscitation fluids merits further research to evaluate the safety and efficacy for prehospital treatment of hypovolemia and trauma.
Asunto(s)
Fluidoterapia/métodos , Resucitación , Choque/terapia , Animales , Dextranos , Hemodinámica/efectos de los fármacos , Infusiones Intravenosas , Inyecciones Espinales , Solución Salina Hipertónica , OvinosRESUMEN
In the present study, we compare resuscitation of bled sheep with hypertonic saline/dextran or hypertonic saline/hetastarch. Unanestherized sheep were subjected to 2h of hemorrhagic hypotension and then resuscitated with 200 ml of 7.5% NaCl solution made up to include either 6% dextran 70 (Macrodex) or 6% hetastarch (Hespan). Both solutions provided an immediate and sustained improvement in arterial pressure and cardiac output. The hypertonic saline/dextran provided a slightly better overall response as mean arterial pressure, cardiac output and central venous pressure were higher in the dextran group at all times post resuscitation. However, only the ddifferences in arterial pressure and initial plasma volume expansion were statistically significant. The somewhat better response to hypertonic saline/dextran may be explained by the higher oncotic pressures generated by dextran compared to equal concentrations of hetastarch
Asunto(s)
Animales , Fluidoterapia/métodos , Resucitación , Choque/terapia , Dextranos/sangre , Hemodinámica , Soluciones Hipertónicas , Presión Osmótica , Ovinos , Almidón/sangreRESUMEN
We resuscitated unanesthetized bled sheep (bled volume = 1.2-1.7 liters) with 200 ml of hypetonic saline/dextran 70 infused either through a peripheral vein (n=6) or directly into the red marrow of the sternum (n = 6). Intraosseous infusion of the viscous 7.5% NaCl/6% dextran solution required 2-4 min. Plasma sodium was rapidly increased to the same level n both groups demonstrating equally rapid entry into the vascular space. Both regimens provide rapid and sustained normalization of arterial pressure and cardiac output. No significant differences between the two groups were apparent for any measured variable. Intraosseous infusion of hypertonic resuscitation fluids merits further research to evaluate the safety and efficacy for prehspital treatment of hypovolemia and trauma
Asunto(s)
Animales , Fluidoterapia/métodos , Resucitación , Choque/terapia , Dextranos , Hemodinámica/efectos de los fármacos , Infusiones Intravenosas , Inyecciones Espinales , Solución Salina Hipertónica , OvinosRESUMEN
SIR, - Dr Crawford says that nerve grafting should not be doe in leprosy, because the sensory loss leading to burns, trophic ulcers, cellulitis, osteomyelitis, and bone resorption is due to a generalised peripheral neuropathy rather than a localised lesion of peripheral nerves.
Asunto(s)
Humanos , Enfermedades del Sistema Nervioso Periférico/cirugía , Enfermedades del Sistema Nervioso Periférico/etiología , Lepra/cirugía , Lepra/complicaciones , Tejido Nervioso/trasplante , Trasplante HomólogoRESUMEN
The most serious disability from which patients with leprosy suffer is sensory