Asunto(s)

Hipolipemiantes/farmacología , Saponinas/farmacología , Animales , Secuencia de Carbohidratos , Colesterol en la Dieta/administración & dosificación , Cricetinae , Hipolipemiantes/química , Hipolipemiantes/farmacocinética , Datos de Secuencia Molecular , Saponinas/química , Saponinas/farmacocinética

RESUMEN

A detailed commercial process for the synthesis and purification of the activated disaccharide, alpha-D-cellobiosyl bromide heptaacetate (1) was developed. Reaction of alpha-D-cellobiose octaacetate (CBO) with HBr in glacial acetic acid or in glacial acetic acid/methylene chloride combination affords alpha-D-cellobiosyl bromide heptaacetate in high yield and excellent quality. Process variables such as reaction solvent, reaction time, reaction temperature, HBr stoichiometry, isolation methods and product purification options were optimized for large-scale synthesis. alpha-D-Cellobiosyl bromide heptaacetate was successfully prepared in a commercial manufacturing plant.

Asunto(s)

Acetatos/síntesis química , Celobiosa/análogos & derivados , Disacáridos/síntesis química , Acetatos/aislamiento & purificación , Secuencia de Carbohidratos , Celobiosa/síntesis química , Cromatografía Líquida de Alta Presión , Disacáridos/aislamiento & purificación , Filtración , Ácido Bromhídrico , Espectroscopía de Resonancia Magnética , Datos de Secuencia Molecular , Estructura Molecular