RESUMEN

The synthesis and fasciolicidal activity of 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide are reported. A single dose of 15 mg/kg was effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep. Single oral doses up to 400 mg/kg were tolerated by sheep without gross toxic symptoms.

Asunto(s)

Antihelmínticos/uso terapéutico , Fascioliasis/tratamiento farmacológico , Sulfonamidas/uso terapéutico , Animales , Antihelmínticos/síntesis química , Antihelmínticos/toxicidad , Bovinos , Fasciola hepatica , Ovinos , Sulfanilamidas , Sulfonamidas/síntesis química , Sulfonamidas/toxicidad , Tricloroetileno/análogos & derivados , Tricloroetileno/síntesis química , Tricloroetileno/uso terapéutico