RESUMEN

Two lines of investigation suggested that xanthine oxidase- (XO) derived O2 metabolites contribute to paraquat- (PQ) induced acute lung injury. First, PQ treatment increased lung XO activity and decreased lung xanthine dehydrogenase activity. Second, lung albumin uptake increased compared with control values in untreated XO-replete but not tungsten-treated XO-depleted lungs in rats treated with PQ.

Asunto(s)

Enfermedades Pulmonares/inducido químicamente , Pulmón/enzimología , Paraquat/toxicidad , Xantina Oxidasa/metabolismo , Albúminas/metabolismo , Animales , Pulmón/efectos de los fármacos , Enfermedades Pulmonares/enzimología , Masculino , Ratas , Ratas Endogámicas , Tungsteno/farmacología , Xantina Deshidrogenasa/metabolismo