RESUMEN

It was recently suggested that the Kibra polymorphism rs17070145 has a strong effect on multiple episodic memory tasks in humans. We attempted to replicate this using two cohorts of European genetic origin (n = 319 and n = 365). We found no association with either the original SNP or a set of tagging SNPs in the Kibra gene with multiple verbal memory tasks, including one that was an exact replication (Auditory Verbal Learning Task, AVLT). These results suggest that Kibra does not have a strong and general effect on human memory.

Asunto(s)

Memoria/fisiología , Proteínas/genética , Estudios de Cohortes , Europa (Continente) , Humanos , Péptidos y Proteínas de Señalización Intracelular , Fosfoproteínas , Polimorfismo de Nucleótido Simple , Proteínas/fisiología , Reproducibilidad de los Resultados , Población Blanca