RESUMEN
Medico-dosimetric register is an optimal model of epidemiological studies on evaluation of ionizing radiation effects. Regional medico-dosimetric register (RMDR) is a system of interrelating information blocks including data on Siberian Group of Chemical Enterprises (SGCE) personnel. At present SGCE personnel and Seversk residents RMDR database includes information on 138496 persons, 65538 of which are SGCE workers. SGCE personnel and Seversk residents RMDR is a scientific base for researches with the aim of evaluating long-term ionizing radiation effects in a "low" dose range. Information on mortality and morbidity rate as well as "thematic" registers of the main diseases potentiates in evaluating the spectrum of somatic stochastic effects and radiogenic risks in SGCE workers and Seversk residents as well as their offsprings. A practical significance of RMDR database is the formation of the main diseases "risk" groups depending on definite risk factors in certain groups that provides targeted diagnostic and preventive therapy both among high-dose establishments' workers and residents living near-by.
Asunto(s)
Industria Química , Bases de Datos Factuales , Enfermedades Profesionales/epidemiología , Exposición Profesional , Traumatismos por Radiación/epidemiología , Sistema de Registros , Relación Dosis-Respuesta en la Radiación , Femenino , Humanos , Masculino , Modelos Biológicos , Enfermedades Profesionales/mortalidad , Salud Laboral/estadística & datos numéricos , Traumatismos por Radiación/mortalidad , Radiación Ionizante , Factores de Riesgo , Vigilancia de Guardia , Siberia/epidemiología , Recursos HumanosRESUMEN
Possibilities of correction and prophylaxis. The authors presented results of study covering workers of radiation-dangerous plants of Siberian Chemical Enterprise, who underwent long-term exposure to outer and inner radiation in "low" doses range during the occupational activity. Target-systems for radiation effects were proved to be lipid peroxidation and antioxidant defence systems, cell energy metabolism--severity of disorders in which is correlated with degree of radiation exposure.
Asunto(s)
Homeostasis/efectos de la radiación , Enfermedades Profesionales/metabolismo , Exposición Profesional/efectos adversos , Traumatismos por Radiación/metabolismo , Radiación Ionizante , Adulto , Relación Dosis-Respuesta en la Radiación , Estudios de Seguimiento , Humanos , Peroxidación de Lípido/fisiología , Peroxidación de Lípido/efectos de la radiación , Persona de Mediana Edad , Estudios RetrospectivosRESUMEN
To develop some individual prognostic criteria of SLE clinical course the Wald's analysis of immunogenetic markers (HLA) was used. The obtained summarized diagnostic coefficients allow predicting a subacute or chronic pattern of the disease, the rate of generalization and the most frequent location of the process in certain organs. The constant character of HLA-typing results and the simplicity of the given prognostic tables made the proposed diagnostic method convenient for medical practice.
Asunto(s)
Lupus Eritematoso Sistémico/diagnóstico , Enfermedad Aguda , Adolescente , Adulto , Enfermedad Crónica , Progresión de la Enfermedad , Femenino , Antígenos HLA/sangre , Humanos , Inmunogenética , Masculino , Persona de Mediana Edad , Fenotipo , PronósticoRESUMEN
HLA antigens were compared in groups of patients with disseminated sclerosis and healthy donors. In remission group as compared with controls, increased were the rates of A9, B7, B13, B35, A0/B17, A1/B7, A9/B7, A3/B35, A11/B7, A11/B8, B5, B7, 15, and in the progredient group--B7, Bw22, B35, A1/B7, A2/B7, A2/B35, A9/B7, B7, 12. These groups were different only in A11/B7 rates. Remitting and progredient course of the disease in women differed in A3 and A10 rates, in men in A2 and A11. In men with remitting course the A2 antigen rate was substantially lower than in any other group. With respect to the disease duration and the degree of patients's invalidization, the groups of benign, malignant, and intermediate course were singled out differing from each other and controls also in their HLA composition.
Asunto(s)
Antígenos HLA-A/análisis , Antígenos HLA-B/análisis , Esclerosis Múltiple/inmunología , Adolescente , Adulto , Femenino , Antígenos HLA-A/genética , Antígenos HLA-B/genética , Humanos , Masculino , Persona de Mediana Edad , Esclerosis Múltiple/genética , Fenotipo , Pronóstico , Índice de Severidad de la Enfermedad , Factores SexualesRESUMEN
The contents of class 1 HLA antigens was compared in patients with disseminated sclerosis, their first-grade relatives and healthy donors. Patients, as compared to healthy persons, had higher occurrence rate of A1, A9, B7, A0/B0, A9/B7, A1/B7, A1/B12, A2/B7, B7, 27, B5, 0, B7, 12, B7, 15, B5, 7, and lower A28, B13, Bw22, B35, 40, B7, 35, A2, w19, A0/B35, A0/B13, A2/B15, A3/B35. In male patients, as compared to female patients, B40 and A1/B15 were more frequent, and B12 less frequent. The subgroup of patients with the diseases onset before 20 years considerably differed from other patients in their rates of A1, A1, 2, A1w19, A1/B0 increased and A3 and A9/B17 decreased. Compared to donor group, the patients' relatives had differences similar to those between patients and relatives. High relative risk values were characteristic of some of the above associations.