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Involvement of sortase anchoring of cell wall proteins in biofilm formation by Streptococcus mutans.
Infect Immun
; 73(6): 3773-7, 2005 Jun.
Artículo
en Inglés
| MEDLINE
| ID: mdl-15908410
RESUMEN
Streptococcus mutans is one of the best-known biofilm-forming organisms associated with humans. We investigated the role of the sortase gene (srtA) in monospecies biofilm formation and observed that inactivation of srtA caused a decrease in biofilm formation. Genes encoding three putative sortase-dependent proteins were also found to be up-regulated in biofilms versus planktonic cells and mutations in these genes resulted in reduced biofilm biomass.