RESUMEN
Gait analysis has traditionally been carried out in a laboratory environment using expensive equipment, but, recently, reliable, affordable, and wearable sensors have enabled integration into clinical applications as well as use during activities of daily living. Real-time gait analysis is key to the development of gait rehabilitation techniques and assistive devices such as neuroprostheses. This article presents a systematic review of wearable sensors and techniques used in real-time gait analysis, and their application to pathological gait. From four major scientific databases, we identified 1262 articles of which 113 were analyzed in full-text. We found that heel strike and toe off are the most sought-after gait events. Inertial measurement units (IMU) are the most widely used wearable sensors and the shank and foot are the preferred placements. Insole pressure sensors are the most common sensors for ground-truth validation for IMU-based gait detection. Rule-based techniques relying on threshold or peak detection are the most widely used gait detection method. The heterogeneity of evaluation criteria prevented quantitative performance comparison of all methods. Although most studies predicted that the proposed methods would work on pathological gait, less than one third were validated on such data. Clinical applications of gait detection algorithms were considered, and we recommend a combination of IMU and rule-based methods as an optimal solution.
Asunto(s)
Actividades Cotidianas , Dispositivos Electrónicos Vestibles , Fenómenos Biomecánicos , Marcha , Análisis de la Marcha , HumanosRESUMEN
Spinal cord injury leads to severe locomotor deficits or even complete leg paralysis. Here we introduce targeted spinal cord stimulation neurotechnologies that enabled voluntary control of walking in individuals who had sustained a spinal cord injury more than four years ago and presented with permanent motor deficits or complete paralysis despite extensive rehabilitation. Using an implanted pulse generator with real-time triggering capabilities, we delivered trains of spatially selective stimulation to the lumbosacral spinal cord with timing that coincided with the intended movement. Within one week, this spatiotemporal stimulation had re-established adaptive control of paralysed muscles during overground walking. Locomotor performance improved during rehabilitation. After a few months, participants regained voluntary control over previously paralysed muscles without stimulation and could walk or cycle in ecological settings during spatiotemporal stimulation. These results establish a technological framework for improving neurological recovery and supporting the activities of daily living after spinal cord injury.
Asunto(s)
Tecnología Biomédica , Terapia por Estimulación Eléctrica , Parálisis/rehabilitación , Traumatismos de la Médula Espinal/rehabilitación , Caminata/fisiología , Actividades Cotidianas , Simulación por Computador , Electromiografía , Espacio Epidural , Humanos , Pierna/inervación , Pierna/fisiología , Pierna/fisiopatología , Locomoción/fisiología , Masculino , Neuronas Motoras/fisiología , Músculo Esquelético/inervación , Músculo Esquelético/fisiología , Músculo Esquelético/fisiopatología , Parálisis/fisiopatología , Parálisis/cirugía , Médula Espinal/citología , Médula Espinal/fisiología , Médula Espinal/fisiopatología , Traumatismos de la Médula Espinal/fisiopatología , Traumatismos de la Médula Espinal/cirugíaRESUMEN
After spinal cord injury (SCI), sensory feedback circuits critically contribute to leg motor execution. Compelled by the importance to engage these circuits during gait rehabilitation, assistive robotics and training protocols have primarily focused on guiding leg movements to reinforce sensory feedback. Despite the importance of trunk postural dynamics on gait and balance, trunk assistance has comparatively received little attention. Typically, trunk movements are either constrained within bodyweight support systems, or manually adjusted by therapists. Here, we show that real-time control of trunk posture re-established dynamic balance amongst bilateral proprioceptive feedback circuits, and thereby restored left-right symmetry, loading and stepping consistency in rats with severe SCI. We developed a robotic system that adjusts mediolateral trunk posture during locomotion. This system uncovered robust relationships between trunk orientation and the modulation of bilateral leg kinematics and muscle activity. Computer simulations suggested that these modulations emerged from corrections in the balance between flexor- and extensor-related proprioceptive feedback. We leveraged this knowledge to engineer control policies that regulate trunk orientation and postural sway in real-time. This dynamical postural interface immediately improved stepping quality in all rats regardless of broad differences in deficits. These results emphasize the importance of trunk regulation to optimize performance during rehabilitation.
Asunto(s)
Retroalimentación Sensorial , Marcha , Pierna/fisiopatología , Locomoción , Postura , Traumatismos de la Médula Espinal/fisiopatología , Animales , Femenino , Humanos , Modelos Teóricos , Desempeño Psicomotor , Ratas , Traumatismos de la Médula Espinal/rehabilitación , Interfaz Usuario-ComputadorRESUMEN
Gait recovery after neurological disorders requires remastering the interplay between body mechanics and gravitational forces. Despite the importance of gravity-dependent gait interactions and active participation for promoting this learning, these essential components of gait rehabilitation have received comparatively little attention. To address these issues, we developed an adaptive algorithm that personalizes multidirectional forces applied to the trunk based on patient-specific motor deficits. Implementation of this algorithm in a robotic interface reestablished gait dynamics during highly participative locomotion within a large and safe environment. This multidirectional gravity-assist enabled natural walking in nonambulatory individuals with spinal cord injury or stroke and enhanced skilled locomotor control in the less-impaired subjects. A 1-hour training session with multidirectional gravity-assist improved locomotor performance tested without robotic assistance immediately after training, whereas walking the same distance on a treadmill did not ameliorate gait. These results highlight the importance of precise trunk support to deliver gait rehabilitation protocols and establish a practical framework to apply these concepts in clinical routine.
Asunto(s)
Algoritmos , Locomoción/fisiología , Traumatismos de la Médula Espinal/rehabilitación , Rehabilitación de Accidente Cerebrovascular/métodos , Marcha/fisiología , Humanos , RobóticaRESUMEN
Robotic exoskeletons provide programmable, consistent and controllable active therapeutic assistance to patients with neurological disorders. Here we introduce a prototype and preliminary experimental evaluation of a rehabilitative gait exoskeleton that enables compliant yet effective manipulation of the fragile limbs of rats. To assist the displacements of the lower limbs without impeding natural gait movements, we designed and fabricated soft pneumatic actuators (SPAs). The exoskeleton integrates two customizable SPAs that are attached to a limb. This configuration enables a 1 N force load, a range of motion exceeding 80 mm in the major axis, and speed of actuation reaching two gait cycles/s. Preliminary experiments in rats with spinal cord injury validated the basic features of the exoskeleton. We propose strategies to improve the performance of the robot and discuss the potential of SPAs for the design of other wearable interfaces.
Asunto(s)
Miembros Artificiales/veterinaria , Dispositivo Exoesqueleto/veterinaria , Trastornos Neurológicos de la Marcha/fisiopatología , Trastornos Neurológicos de la Marcha/rehabilitación , Rehabilitación Neurológica/instrumentación , Robótica/instrumentación , Animales , Módulo de Elasticidad , Diseño de Equipo/veterinaria , Análisis de Falla de Equipo , Estudios de Factibilidad , Femenino , Trastornos Neurológicos de la Marcha/diagnóstico , Proyectos Piloto , Ratas , Ratas Endogámicas Lew , Reproducibilidad de los Resultados , Sensibilidad y Especificidad , Resultado del TratamientoRESUMEN
OBJECTIVES: We aimed to develop a robotic interface capable of providing finely-tuned, multidirectional trunk assistance adjusted in real-time during unconstrained locomotion in rats and mice. APPROACH: We interfaced a large-scale robotic structure actuated in four degrees of freedom to exchangeable attachment modules exhibiting selective compliance along distinct directions. This combination allowed high-precision force and torque control in multiple directions over a large workspace. We next designed a neurorobotic platform wherein real-time kinematics and physiological signals directly adjust robotic actuation and prosthetic actions. We tested the performance of this platform in both rats and mice with spinal cord injury. MAIN RESULTS: Kinematic analyses showed that the robotic interface did not impede locomotor movements of lightweight mice that walked freely along paths with changing directions and height profiles. Personalized trunk assistance instantly enabled coordinated locomotion in mice and rats with severe hindlimb motor deficits. Closed-loop control of robotic actuation based on ongoing movement features enabled real-time control of electromyographic activity in anti-gravity muscles during locomotion. SIGNIFICANCE: This neurorobotic platform will support the study of the mechanisms underlying the therapeutic effects of locomotor prosthetics and rehabilitation using high-resolution genetic tools in rodent models.
Asunto(s)
Diseño de Equipo/métodos , Locomoción/fisiología , Prótesis Neurales , Robótica/métodos , Animales , Femenino , Miembro Posterior/inervación , Miembro Posterior/fisiopatología , Miembro Posterior/cirugía , Ratones , Ratones Endogámicos C57BL , Prótesis Neurales/tendencias , Ratas , Ratas Endogámicas Lew , Robótica/tendencias , Traumatismos de la Médula Espinal/fisiopatología , Traumatismos de la Médula Espinal/rehabilitación , Traumatismos de la Médula Espinal/cirugíaRESUMEN
Rocking movements are known to affect human sleep. Previous studies have demonstrated that the transition from wake to sleep can be facilitated by rocking movements, which might be related to relaxation. However, it is not yet known which movements would have the greatest effect. Thus, a 6-degree-of-freedom tendon-based robotic bed was developed, for systematic evaluation of vestibular stimuli. The applicability of the device was evaluated with 25 subjects. Six movement axes were tested and analyzed for differences in promoting relaxation. Relaxation was assessed by electroencephalogram, electrocardiogram, respiration and a questionnaire. The developed device fulfilled all needed requirements proving the applicability of this technology. Movements had no significant effects on the electroencephalogram and electrocardiogram. Respiration frequency was significantly lower for baseline measurements without movement (median 0.183-0.233 Hz) compared to movement conditions (median 0.283-0.300 Hz). Questionnaire ratings showed a trend (p = 0.057) toward higher relaxation for movements along the vertical axis (z-axis) (median 4.67; confidence interval 4.33-5.67) compared to the roll-axis (median 4.33; confidence interval 3.67-5.00). Movements along the vertical axis (z-axis), therefore, appear most promising in promoting relaxation, though no effects were found in electroencephalogram and electrocardiogram variables. This lack of effect might be attributed to the short exposure to the movements and the large inter-individual variability and individual preferences among subjects.
Asunto(s)
Lechos , Vestíbulo del Laberinto/fisiología , Acústica , Adulto , Electroencefalografía , Frecuencia Cardíaca/fisiología , Humanos , Masculino , Persona de Mediana Edad , Ruido , Reproducibilidad de los Resultados , Respiración , Robótica , Encuestas y Cuestionarios , Adulto JovenRESUMEN
Spinal cord injury leads to a range of disabilities, including limitations in locomotor activity, that seriously diminish the patients' autonomy and quality of life. Electrochemical neuromodulation therapies, robot-assisted rehabilitation and willpower-based training paradigms restored supraspinal control of locomotion in rodent models of severe spinal cord injury. This treatment promoted extensive and ubiquitous remodeling of spared circuits and residual neural pathways. In four chronic paraplegic individuals, electrical neuromodulation of the spinal cord resulted in the immediate recovery of voluntary leg movements, suggesting that the therapeutic concepts developed in rodent models may also apply to humans. Here, we briefly review previous work, summarize current developments, and highlight impediments to translate these interventions into medical practice to improve functional recovery of spinal-cord-injured individuals.
Asunto(s)
Terapia por Estimulación Eléctrica , Traumatismos de la Médula Espinal/rehabilitación , Animales , Técnicas Electroquímicas , Potenciales Evocados Motores , Humanos , Neuronas Motoras/fisiología , Músculo Esquelético/fisiología , Plasticidad Neuronal , Prótesis e Implantes , Traumatismos de la Médula Espinal/fisiopatología , Caminata/fisiologíaRESUMEN
Gait rehabilitation robots are of increasing importance in neurorehabilitation. Conventional devices are often criticized because they are limited to reproducing predefined movement patterns. Research on patient-cooperative control strategies aims at improving robotic behavior. Robots should support patients only as much as needed and stimulate them to produce maximal voluntary efforts. This paper presents a patient-cooperative strategy that allows patients to influence the timing of their leg movements along a physiologically meaningful path. In this "path control" strategy, compliant virtual walls keep the patient's legs within a "tunnel" around the desired spatial path. Additional supportive torques enable patients to move along the path with reduced effort. Graphical feedback provides visual training instructions. The path control strategy was evaluated with 10 healthy subjects and 15 subjects with incomplete spinal cord injury. The spatio-temporal characteristics of recorded kinematic data showed that subjects walked with larger temporal variability with the new strategy. Electromyographic data indicated that subjects were training more actively. A majority of iSCI subjects was able to actively control their gait timing. Thus, the strategy allows patients to train walking while being helped rather than controlled by the robot.
Asunto(s)
Trastornos Neurológicos de la Marcha/fisiopatología , Trastornos Neurológicos de la Marcha/rehabilitación , Pierna/fisiopatología , Sistemas Hombre-Máquina , Robótica/métodos , Terapia Asistida por Computador/métodos , Interfaz Usuario-Computador , Humanos , Masculino , Modalidades de FisioterapiaRESUMEN
Robot-aided treadmill training is an innovative rehabilitation method for patients with locomotor dysfunctions. However, in current rehabilitation systems treadmill speed is restricted to constant values or adjusted by the therapist, whereas self-determined phases of accelerations and decelerations cannot be performed by the patient in an interactive and intuitive way. We present a new approach that allows treadmill walking with intuitive gait speed adaptation. In this approach, the user's trunk position is fixed in walking direction. The horizontal interaction forces applied by the user intending to accelerate or decelerate the gait are measured at the trunk connection and fed to the treadmill controller. The desired gait acceleration is calculated by means of a virtual admittance. Integration yields the desired speed which is fed into the underlying velocity controller of the treadmill. The method was verified by two experimental setups and tested on ten healthy subjects. In one setup, the subject's trunk was rigidly connected by a tether, whereas in the second setup the subject was placed in a robotic gait orthosis. All subjects were able to use both systems immediately and intuitively. The treadmill speed profile during the gait cycle corresponds to that of normal walking. The controller can be extended to simulate different walking conditions, such as slope walking. The method can be used for patient-cooperative control strategies performed with a robotic gait orthosis as well as for any other user-interactive applications in fitness and sports.
Asunto(s)
Algoritmos , Prueba de Esfuerzo/instrumentación , Trastornos Neurológicos de la Marcha/rehabilitación , Sistemas Hombre-Máquina , Robótica/instrumentación , Terapia Asistida por Computador/instrumentación , Adulto , Diseño de Equipo , Análisis de Falla de Equipo , Prueba de Esfuerzo/métodos , Humanos , Masculino , Persona de Mediana Edad , Robótica/métodos , Terapia Asistida por Computador/métodosRESUMEN
The rehabilitation robot LOKOMAT has been developed at the Balgrist University Hospital to automate treadmill training of spinal cord injury and stroke patients. A virtual environment setup was implemented to increase patient's motivation and provide biofeedback, consisting of visual, acoustic and haptic modalities. Based on the knee and hip angles of the orthosis, an animated figurine moves through a virtual environment. This contribution describes the setup of the system and selected technical performance parameters. We focused on delay times caused by the setup, stability of the haptic obstacle rendering and on the level of immersion as judged by four healthy subjects. Results show that subjects judged the system's performance well (questionnaire scores over 80%). Problems exist though for obstacle rendering (questionnaire scores of 55%).