RESUMEN

Peptide fragments of conservative sites of PorA, OpaB, and NspA proteins of the outer membrane of serogroup B meningococci were synthesized. These peptides caused a pronounced protective effect in immunized mice infected with virulent homologous and heterologous strains of serogroups B and A meningococci. The protective effect appreciably increased, if the studied peptides were associated in a polycomponent preparation, which can be used in the construction of meningococcal bivalent B+A vaccine.

Asunto(s)

Proteínas de la Membrana Bacteriana Externa/inmunología , Neisseria meningitidis Serogrupo B/metabolismo , Péptidos/inmunología , Secuencia de Aminoácidos , Animales , Proteínas de la Membrana Bacteriana Externa/genética , Infecciones Meningocócicas/inmunología , Infecciones Meningocócicas/prevención & control , Vacunas Meningococicas , Ratones , Datos de Secuencia Molecular , Neisseria meningitidis Serogrupo B/química , Neisseria meningitidis Serogrupo B/patogenicidad , Péptidos/genética