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[Correcting influence of vitamin E short chain derivatives on lipid peroxidation, liver cell membrane, and chromatin structure when rats are exposed to embichin]. / Korihiuchyi vplyv korotkolantsiuhovoho pokhidnoho vitaminu E na stan protsesiv POL ta strukturuu membran i khromatynu klityn pechinky shchuriv za diï embikhinu.
Kovalenko, V M; Byshovets', T F; Hubs'kyi, Iu I; Levyts'kyi, Ie L; Shaiakhmetova, H M; Marchenko, O M; Voloshyna, O S; Saifetdinova, H A; Okhrimenko, V O; Donchenko, H V.
Ukr Biokhim Zh (1999) ; 72(2): 56-60, 2000.
Artículo en Ucraniano | MEDLINE | ID: mdl-10979582

RESUMEN

Embikhin causes activation of LPO processes in endoplasmic reticulum and in nuclear chromatine fractions of rat liver cells. The latter is accompanied by the impairment of repressive and active nuclear chromatine fractions structure. Derivate of vitamin E in these conditions renders correcting action on parameters of lipid peroxidation in the investigated subcellular structures, testifying its positive influence on the cell heredity apparatus state. The normalizing action of tocopherol derivative on cytochromes P450 and b5 levels is shown.


Asunto(s)
Cromatina/química , Peroxidación de Lípido/efectos de los fármacos , Hígado/efectos de los fármacos , Mecloretamina/farmacología , Vitamina E/análogos & derivados , Animales , Membrana Celular/efectos de los fármacos , Hígado/metabolismo , Masculino , Conformación Proteica , Ratas , Vitamina E/farmacología
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