RESUMEN
Changes in the adrenergic nervous system and population of tissue basophils of human spinal arteries in the course of 24 h after a blunt injury to the spine were studied. A staged pattern of development of compensatory adaptive reaction of the mechanisms regulating the spinal circulation has been revealed. The detected time course of posttraumatic changes may be interesting as it concerns the diagnosis of the time when a blunt injury to the spine was inflicted.
Asunto(s)
Arterias/inervación , Monoaminas Biogénicas/metabolismo , Cambios Post Mortem , Traumatismos de la Médula Espinal/patología , Médula Espinal/irrigación sanguínea , Traumatismos Vertebrales/patología , Heridas no Penetrantes/patología , Adolescente , Fibras Adrenérgicas/metabolismo , Fibras Adrenérgicas/patología , Adulto , Arterias/metabolismo , Traumatismos por Electricidad/metabolismo , Traumatismos por Electricidad/patología , Femenino , Histocitoquímica , Humanos , Masculino , Mastocitos/metabolismo , Mastocitos/patología , Médula Espinal/metabolismo , Traumatismos de la Médula Espinal/complicaciones , Traumatismos de la Médula Espinal/metabolismo , Traumatismos Vertebrales/complicaciones , Traumatismos Vertebrales/metabolismo , Factores de Tiempo , Heridas no Penetrantes/complicaciones , Heridas no Penetrantes/metabolismoRESUMEN
Time course of the activities of transport enzymes in capillary walls of human spinal cord was studied in various periods after closed injury to the cord, inflicted by hard blunt objects, with the use of histochemical methods for the detection of alkaline phosphatase and Mg-dependent ATPase. Wave-like fluctuations in the activities of the examined enzymes were revealed. The findings may be used to assess the period elapsed since the cord injury.
Asunto(s)
Pruebas Enzimáticas Clínicas , Traumatismos de la Médula Espinal/diagnóstico , Médula Espinal/enzimología , Heridas no Penetrantes/diagnóstico , Adulto , Fosfatasa Alcalina/análisis , Autopsia/métodos , ATPasa de Ca(2+) y Mg(2+)/análisis , Capilares/enzimología , Pruebas Enzimáticas Clínicas/métodos , Traumatismos por Electricidad/diagnóstico , Femenino , Histocitoquímica , Humanos , Masculino , Médula Espinal/irrigación sanguínea , Factores de TiempoRESUMEN
1. Morphohistological changes in a focus of spinal cord trauma have a phasic character, with a period of primary lesions (5-30 min after traumatization) and a period of secondary lesions (1-23 h after traumatization). 2. Variation of transport enzyme activities in the walls of the microvessels of the traumatized spinal cord is characterized by an undulating course and by asynchrony of the peaks of Mg-dependent ATPase and alkaline phosphatase activity. 3. With reference to the rapid drop in the given enzyme activities and to progressive necrotic changes in the traumatized spinal cord, it is desirable that the cord circulation should be corrected within the first few hours after traumatization.